Publications by authors named "C A G Boreham"
Background: Increasing interest surrounds the utility of blood-based biomarkers for diagnosing sarcopenia. C-terminal agrin fragment (CAF), a marker of neuromuscular junction stability, is amongst the most promising candidates; however, a dearth of reference data impedes the incorporation of its use in public health settings. This study aimed to establish reference values for plasma CAF concentrations across adulthood in a large, well-characterized cohort of healthy adults; and comprehensively examine the association between plasma CAF levels and skeletal muscle health.
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- - The study analyzed the relationship between grip strength and blood pressure (BP) in 9,424 adults aged 18-92, finding a general trend of higher grip strength in individuals with elevated BP, particularly among those who are overweight or obese.
- - After controlling for body mass index (BMI) and body fat percentage (BF%), the association between grip strength and BP was significant in specific groups, suggesting that obesity and body fat influence this relationship.
- - Notably, individuals with low grip strength and high body fat had lower chances of elevated BP, while those with low grip strength and low body fat were more likely to have elevated BP, indicating that BMI and BF% may impact grip strength's effect on BP. *
Background: Although handgrip strength (HGS) asymmetry has clinical screening utility, its relevance to sarcopenia is unknown. This study examined the relationship between HGS asymmetry and sarcopenia signatures, and explored the relevance of circulating neural/neuromuscular markers.
Methods: 9403 individuals aged 18-92 years participated in this study.
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View Article and Find Full Text PDFAlthough physiological data suggest that neuromuscular junction (NMJ) dysfunction is a principal mechanism underpinning sarcopenia, genetic studies have implicated few genes involved in NMJ function. Accordingly, we explored whether genes encoding agrin (AGRN) and neurotrypsin (PRSS12) were associated with sarcopenia phenotypes: muscle mass, strength and plasma C-terminal agrin fragment (CAF). PhenoScanner was used to determine if AGRN and/or PRSS12 variants had previously been implicated with sarcopenia phenotypes.
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