The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells.

Background: The role of angiotensin II (Ang II) in mediating excessive sodium reabsorption in diabetic nephropathy is recognized. Serine-glucocorticoid kinase-1 (SGK-1) increases sodium-hydrogen exchanger-3 (NHE3) expression and is known to be upregulated in in vitro and in vivo models of diabetic nephropathy. However, a link between Ang II and SGK-1 in diabetic nephropathy has not been established.

Effect of histological damage on long-term kidney transplant outcome.

Background: Chronic renal allograft failure remains a major challenge to overcome. Factors such as donor quality, delayed graft function (DGF), acute rejection, and immunosuppression are known to affect long-term outcome, but their relationship to histological damage to graft outcome is unclear.

Methods: Protocol kidney biopsies (n=112) obtained at 3 months after transplantation yielded 102 with adequate tissue.