Publications by authors named "C A Ellsworth"
Article Synopsis
- * Prolonged stress leads to decreased NK cell numbers and functions across various species, with particular age and stress exposure impacting effectiveness; rehabilitation strategies have shown limited success.
- * Differences in stress response are noted between genders, with females showing greater NK cell suppression, and research indicates mice are not ideal models for studying stress effects on NK cells, pointing to the need for further investigation into the mechanisms behind NK cell dysfunction.
Article Synopsis
- Tlr7 deficiency is linked to more severe COVID-19 due to lower production of interferons (IFNs), which are important for the immune response.
- Infected mice show that the virus activates Tlr7 and IFN pathways initially; however, Tlr7 and Irf7 deficiencies lead to worse symptoms and higher viral loads.
- Deficiencies in Tlr7 and Irf7 result in reduced antibody production against SARS-CoV-2, hindering the body's ability to clear the virus effectively.
Enhanced complement activation and MAC formation accelerates severe COVID-19.
Cell Mol Life Sci
September 2024
Emerging evidence indicates that activation of complement system leading to the formation of the membrane attack complex (MAC) plays a detrimental role in COVID-19. However, their pathogenic roles have never been experimentally investigated before. We used three knock out mice strains (1.
View Article and Find Full Text PDFUpregulation of inflammatory genes and pathways links obesity to severe COVID-19.
Biochim Biophys Acta Mol Basis Dis
October 2024
Obesity is a risk factor for developing severe COVID-19. However, the mechanism underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a study in which 2-3-month-old K18-hACE2 (K18) mice were fed a western high-fat diet (WD) or normal chow (NC) over 3 months before intranasal infection with a sublethal dose of SARS-CoV2 WA1 (a strain ancestral to the Wuhan variant).
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