Teaching Caregivers to Use Graduated Guidance Using Video Modeling.

Unlabelled: We evaluated the effects of a video modeling training package on the implementation of graduated guidance instruction for three caregivers of young children with autism spectrum disorder. The video model was narrated and featured a generic model of graduated guidance that was different from the tasks used in the study. One of the caregiver-child dyads participated via telehealth during the COVID-19 pandemic.

Becoming a person-centred facilitator of learning in a hospital setting: Findings from a participatory action-oriented study with hospital-based educators.

Aim: Investigate the experience of hospital-based educators becoming person-centred facilitators of learning.

Background: Hospital-based educators working with staff are not well-prepared for their role. No person-centred pedagogical approaches exist specifically for use in hospital settings.

Dynamic conformational equilibria in the active states of KRAS and NRAS.

The design of potent RAS inhibitors benefits from a molecular understanding of the dynamics in KRAS and NRAS and their oncogenic mutants. Here we characterize switch-1 dynamics in GTP-state KRAS and NRAS by P NMR, by N relaxation dispersion NMR, hydrogen-deuterium exchange mass spectrometry (HDX-MS), and molecular dynamics simulations. In GMPPNP-bound KRAS and NRAS, we see the co-existence of two conformational states, corresponding to an "inactive" state-1 and an "active" state-2, as previously reported.

Exploring the Link Between Early Technology Exposure and Developmental Milestones in Childhood.

Background This study examined the relationship between touchscreen exposure and developmental outcomes in early childhood using the Ages and Stages Questionnaire, Third Edition (ASQ-3), a widely-used developmental screening tool. Methods During a well-child visit, parents of 51 children aged 18-36 months completed the ASQ-3 and a survey on their child's touchscreen habits (timing of introduction, daily usage duration, independent use, engagement in creative activities). Medical records were reviewed for developmental diagnoses and health conditions.

Effectiveness of Implementation of an Enhanced Recovery Program in Bariatric Surgery.

Introduction: While the adoption of ERAS protocols in bariatric surgery has increased, variability exists across centers, reflecting a spectrum of implementation stages. The objective of this study is to understand and increase awareness of the effectiveness of enhanced recovery after surgery (ERAS) protocols in bariatric surgery, given the specific perioperative difficulties and risks for this population. We aimed to study the association between implementation of the ERAS program in bariatric surgery and specific outcomes.