Publications by authors named "C A Dennison"

Transcription factors control genes to maintain normal hemopoiesis, and dysregulation of some factors can lead to acute lymphoblastic leukemia (ALL). Mycoviruses are known to alter the genetics of their fungal host. The present study evaluates the effects of the products of a mycovirus-containing (MCAF), isolated from the home of a patient with ALL, on certain transcription factors of normal and ALL cell lines.

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Article Synopsis
  • Systolic heart failure is characterized by reduced muscle contractility and mitochondrial function, but there is currently no treatment that addresses both issues.
  • Researchers used adeno-associated virus (AAV) to deliver a gene that improves heart function and boosts mitochondrial health in mice, leading to better cardiac performance.
  • The study also reveals that the gene PERM1 interacts with troponin C, a key protein for muscle contraction, and enhances its expression, suggesting a new therapeutic strategy for systolic heart failure.
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Unlabelled: Autotrophic bacteria are able to fix CO in a great diversity of habitats, even though this dissolved gas is relatively scarce at neutral pH and above. As many of these bacteria rely on CO fixation by ribulose 1,5-bisphospate carboxylase/oxygenase (RubisCO) for biomass generation, they must compensate for the catalytical constraints of this enzyme with CO-concentrating mechanisms (CCMs). CCMs consist of CO and HCO transporters and carboxysomes.

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Background: Emotional problems (EPs) increase sharply after mid-adolescence. Earlier EPs are associated with poorer long-term outcomes, and their underlying mechanisms may differ to later-onset EPs. Given an established relationship between ADHD, autism, and later depression, we aimed to examine associations between neurodevelopmental conditions and correlates and early adolescent-onset EPs.

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