Publications by authors named "C A Dempsey"
Article Synopsis
- Potassium channels from the human hERG gene are affected by various drugs, and this study specifically investigates the effects of chiral disopyramide, a Class Ia antiarrhythmic, on hERG currents in HEK 293 cells.* -
- The findings show that the S(+) enantiomer of disopyramide is more potent at inhibiting hERG current compared to the R(-) form, with IC values of 3.9 µM and 12.9 µM respectively, and certain mutations in hERG alter these effects.* -
- Molecular simulations indicate that the S(+) form binds more effectively to specific residues in the hERG channel, while the R(-)
Article Synopsis
- The study investigates Alzheimer's disease-related psychosis (ADP) in older adults, focusing on demographic and clinical differences between those treated with antipsychotics and those who are not.
- Researchers analyzed data from over 145,000 ADP patients, comparing health outcomes related to falls, fractures, seizures, and mortality between the two groups.
- Findings reveal that antipsychotic users had more baseline health issues and higher rates of falls, fractures, and mortality compared to nonusers, indicating a significant impact of antipsychotic treatment on health outcomes in ADP patients.
Background: While food allergy (FA) can be fatal, the greatest public health impact of FA arguably lies in its detrimental effect on quality of life (FAQOL). Understanding the factors that contribute to FAQOL at different ages is essential to develop personalized interventions that will improve FAQOL.
Objective: To determine the most influential factors that impact FAQOL across ages in well-phenotyped participants with confirmed FA.