A novel image segmentation method based on spatial autocorrelation identifies A-type potassium channel clusters in the thalamus.

Unsupervised segmentation in biological and non-biological images is only partially resolved. Segmentation either requires arbitrary thresholds or large teaching datasets. Here, we propose a spatial autocorrelation method based on Local Moran's coefficient to differentiate signal, background, and noise in any type of image.

Liquid Biopsy versus CT: Comparison of Tumor Burden Quantification in 1065 Patients with Metastases.

Background Tumor fraction (TF) at liquid biopsy is a potential noninvasive marker for tumor burden, but validation is needed. Purpose To evaluate TF as a potential surrogate for tumor burden, assessed at contrast-enhanced CT across diverse metastatic cancers. Methods This retrospective monocentric study included patients with cancer and metastatic disease, with TF results and contemporaneous contrast-enhanced CT performed between January 2021 and January 2023.

Climate-Induced Saltwater Intrusion in 2100: Recharge-Driven Severity, Sea Level-Driven Prevalence.

Saltwater intrusion is a critical concern for coastal communities due to its impacts on fresh ecosystems and civil infrastructure. Declining recharge and rising sea level are the two dominant drivers of saltwater intrusion along the land-ocean continuum, but there are currently no global estimates of future saltwater intrusion that synthesize these two spatially variable processes. Here, for the first time, we provide a novel assessment of global saltwater intrusion risk by integrating future recharge and sea level rise while considering the unique geology and topography of coastal regions.

Predicting modular functions and neural coding of behavior from a synaptic wiring diagram.

A long-standing goal in neuroscience is to understand how a circuit's form influences its function. Here, we reconstruct and analyze a synaptic wiring diagram of the larval zebrafish brainstem to predict key functional properties and validate them through comparison with physiological data. We identify modules of strongly connected neurons that turn out to be specialized for different behavioral functions, the control of eye and body movements.