Publications by authors named "C A D'Cruz"
Article Synopsis
- - Capivasertib, a selective pan-AKT inhibitor, was shown to significantly improve progression-free survival when added to fulvestrant compared to fulvestrant alone in patients with advanced breast cancer (P < 0.001), specifically those who had previously experienced disease progression on aromatase inhibitors.
- - In a randomized trial with 708 patients, individuals received either capivasertib plus fulvestrant or a placebo plus fulvestrant, with safety analyses revealing common adverse events (AEs) like diarrhea, rash, and hyperglycemia associated with capivasertib treatment.
- - Among 705 patients analyzed, 72.4% experienced diarrhea, while 38% had a rash
Article Synopsis
- CAPItello-291 is a phase 3 clinical trial studying the effects of capivasertib combined with fulvestrant on progression-free survival in patients with advanced hormone receptor-positive, HER2-negative breast cancer who experienced relapse after aromatase inhibitors.
- The trial involved a diverse group of participants, including both men and women aged 18 and older, and was conducted across 193 centers in 19 countries, focusing on those with a specific type of breast cancer and previous treatment history.
- Researchers also assessed the impact of this treatment on quality of life, symptoms, and tolerability, aiming to analyze how the new combination therapy affects overall health and wellbeing beyond just cancer progression.
People in the LGBTQIA+ community (i.e., lesbian, gay, bisexual, transgender, queer, intersex, asexual, and other gender/sexual minorities) experience greater rates of intimate partner aggression (IPA) than the general population and have fewer help-seeking pathways available.
View Article and Find Full Text PDFThere is a growing recognition that responding to climate change necessitates urban adaptation. We sketch a transdisciplinary research effort, arguing that actionable research on urban adaptation needs to recognize the nature of cities as social networks embedded in physical space. Given the pace, scale and socioeconomic outcomes of urbanization in the Global South, the specificities and history of its cities must be central to the study of how well-known agglomeration effects can facilitate adaptation.
View Article and Find Full Text PDFWheat blast, caused by the fungus pathotype (MoT), is a devastating disease affecting South America, Bangladesh, and Zambia. Resistance to wheat blast has strongly relied on the 2NS translocation; however, newer MoT isolates have increased aggressiveness, threatening the 2NS translocation's effectiveness and durability. To identify genomic regions associated with wheat blast resistance, we performed a quantitative trait loci (QTL) mapping study using 187 double-haploid (DH) lines from a cross between the Brazilian wheat cultivars 'TBIO Alvorada' and 'TBIO Sossego', which are moderately resistant and susceptible to blast, respectively.
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