A portrait of germline pathogenic variants in high and moderate penetrance breast cancer genes in Brazil.

Introduction: The prevalence of germline pathogenic/likely pathogenic variants (P/LP) in high and moderate penetrance (HMP) genes is approximately 7%-10% among breast cancer (BC) patients. The prevalence and spectrum of BC P/LP variants are affected by several factors. There are limited genetic data from Brazilian patients with BC.

Evaluating the synergistic effect of UVC/e-HO applied for benzotriazole degradation in water matrices using catalyst-free printex L6 carbon-based gas diffusion electrode.

The present work investigated the application of UVC combined with electrogenerated HO (UVC/e-HO) for BTA degradation using a Printex L6 carbon-based (PL6C) gas diffusion electrode (GDE). The studies were carried out by analyzing the influence of the current density, pH and initial BTA concentration in the contaminant degradation process. Under optimal conditions using 0.

Cell death by apoptosis induced by (Schott) Mez essential oil in different cancer cell lines.

Cancer is the second leading cause of death in the world. Plants from genus have been studied for their biological activities. Here we evaluated the antitumor activity of essential oil in several cancer cell lines and its phytochemical composition.

Migraine and cognitive dysfunction: a narrative review.

The association between migraine and cognitive function has been studied during the last decade, however, this relationship is not well established. As migraine prevalence is highest between the ages of 30-40, aligning with some of our most productive years, we must understand cognitive changes within this disorder. Cognitive impairment potentially limits social and professional interactions, thus negatively impacting quality of life.

Unravelling the potential of natural chelating agents in the control of Staphylococcus aureus and Pseudomonas aeruginosa biofilms.

Iron is essential for the formation, maturation and dispersal of bacterial biofilms, playing a crucial role in the physiological and metabolic functions of bacteria as well as in the regulation of virulence. Limited availability of iron can impair the formation of robust biofilms by altering cellular motility, hydrophobicity and protein composition of the bacterial surface. In this study, the antibiofilm activity of two natural iron chelating agents, kojic acid (5-hydroxy-2-hydroxymethyl-4H-pyran-4-one) and maltol (3-hydroxy-2-methyl-4-pyrone), were investigated against Staphylococcus aureus and Pseudomonas aeruginosa.