Publications by authors named "C A Budd"
Deep Reinforcement Learning Based System for Intraoperative Hyperspectral Video Autofocusing.
Med Image Comput Comput Assist Interv
October 2023
Article Synopsis
- Hyperspectral imaging (HSI) offers detailed tissue analysis compared to traditional imaging, which is crucial for surgeries needing precise differentiation.
- Current handheld optical systems face limitations in focal depth, making them less effective for operating room use.
- By integrating a focus-tunable liquid lens and using deep reinforcement learning for video autofocusing, our new approach significantly outperformed traditional methods and received positive feedback from neurosurgeons in usability trials.
Article Synopsis
- Li-Fraumeni syndrome (LFS) is linked to harmful mutations in the TP53 gene, leading to an increased risk of developing various cancers, particularly breast cancer.
- A study reports a family with the TP53 p.R181H variant; while one member was diagnosed with breast cancer at 71, other relatives also had breast cancer after 40, though many did not develop cancer by age 42.
- Research indicates that the p.R181H variant might have reduced cancer risk and penetrance, especially in younger individuals, consistent with laboratory findings showing it retains some p53 function.
Rapid and robust endoscopic content area estimation: A lean GPU-based pipeline and curated benchmark dataset.
Comput Methods Biomech Biomed Eng Imaging Vis
July 2023
Endoscopic content area refers to the informative area enclosed by the dark, non-informative, border regions present in most endoscopic footage. The estimation of the content area is a common task in endoscopic image processing and computer vision pipelines. Despite the apparent simplicity of the problem, several factors make reliable real-time estimation surprisingly challenging.
View Article and Find Full Text PDFSeveral cancer predisposition syndromes (CPS) are reported to predispose to rhabdomyosarcoma, most frequently in children with embryonal rhabdomyosarcoma. There are lingering questions over the role of CPS in individuals with alveolar rhabdomyosarcoma (ARMS), which are frequently driven by FOXO1 fusion oncoproteins. We conducted a systematic review to identify patients with FOXO1 fusion-positive ARMS (FP-ARMS) who underwent germline DNA sequencing.
View Article and Find Full Text PDFPazopanib, a receptor tyrosine kinase inhibitor, exhibits anti-tumor activity in adult bone and soft-tissue sarcomas (STS), but has not yet been approved for pediatric tumors. The primary objective was to evaluate pazopanib efficacy when used alone or in combination with topotecan. This real-world multicenter retrospective study included patients with solid tumors, aged 25 years or less at the time of initial diagnosis, treated with pazopanib outside of a clinical trial.
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