Publications by authors named "C A Bonfiglio"
Article Synopsis
- Steatotic liver disease linked to metabolic dysfunction (MASLD) is prevalent in up to 30% of adults and is often associated with obesity and metabolic syndrome.
- The study involved 42 patients split into three groups receiving different treatments: dietary advice only (CG), dietary advice plus aerobic exercise (AE + DA), and dietary advice plus high-intensity interval training (HIIT + DA).
- Results showed that both exercise groups had significant reductions in cortisol levels, with HIIT + DA showing the greatest effects, and a notable decrease in hepatic steatosis was also observed, particularly in the AE + DA group.
Article Synopsis
- IBS and obesity can lead to alterations in the intestinal barrier, causing low-grade inflammation, which can be monitored using zonulin and intestinal fatty acid-binding protein (I-FABP) levels, along with urinary indican concentrations.
- A 12-week Fitwalking program was tested on 57 mild IBS patients divided into obese, overweight, and normal weight groups, who walked three times a week, but no significant changes in most health metrics were found.
- Despite limited changes in biochemical aspects, Fitwalking notably improved physical capacity in all groups and led to a decrease in inflammation levels, particularly in obese individuals, suggesting regular exercise may benefit gut health in this population.
Background: Heart failure (HF) is strongly associated with inflammation. In pressure overload (PO)-induced HF, cardiac stress triggers adaptive immunity, ablation or inhibition of which blocks disease progression. We hypothesized that PO-HF might fulfill the often-used criteria of autoimmunity: if so, the associated adaptive immune response would be not only necessary but also sufficient to induce HF; it should also be possible to identify self-antigens driving the autoimmune response.
View Article and Find Full Text PDFIrritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal (GI) disorder characterized by abdominal pain, altered bowel habits, and bloating, affecting approximately 10.1% of the global population. While current treatments emphasize dietary modifications and symptom management, emerging evidence suggests that physical activity (PA) may help alleviate IBS symptoms.
View Article and Find Full Text PDFBackground: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most recent definition for steatotic liver disease associated with metabolic syndrome. The results of recent metabolic and observational studies suggest a potential beneficial effect of food-derived flavonoids in some chronic diseases, including MASLD. The study aims to evaluate the protective role of diet flavonoids in subjects with and without MASLD belonging to a cohort living in the South of Italy.
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