Publications by authors named "C A Boeger"
Article Synopsis
- This study focused on developing a high-throughput screening method to identify new treatment targets for AP-4 deficiency, a rare childhood disease that causes problems with protein transport in cells.
- Researchers screened a large library of 28,864 small molecules and found a promising lead compound that corrected the mislocalization of the autophagy protein ATG9A in various disease models, including patient-derived cells.
- The study used advanced techniques to investigate how the lead compound affects molecular targets and cellular mechanisms, ultimately providing crucial insights for future drug development aimed at treating AP-4 deficiency.
Background & Aims: RNase H2 is a holoenzyme, composed of 3 subunits (ribonuclease H2 subunits A, B, and C), that cleaves RNA:DNA hybrids and removes mis-incorporated ribonucleotides from genomic DNA through ribonucleotide excision repair. Ribonucleotide incorporation by eukaryotic DNA polymerases occurs during every round of genome duplication and produces the most frequent type of naturally occurring DNA lesion. We investigated whether intestinal epithelial proliferation requires RNase H2 function and whether RNase H2 activity is disrupted during intestinal carcinogenesis.
View Article and Find Full Text PDFBackground: Aldosterone seems to play a role in the development of chronic renal failure and proteinuria. We investigated the adrenal aldosterone production and the adrenal renin-angiotensin system (RAS) in rats with 5/6 nephrectomy with and without spironolactone treatment.
Methods: Sprague-Dawley rats underwent 5/6, 4/6 nephrectomy, heminephrectomy and sham operation.
Background: In peripheral arterial disease (PAD) atherosclerosis is disseminated and thrombosis risk is high. We have not only shown the platelets of PAD patients to by hyperreactive and aspirin resistant, but have recently verified them to be hypersensitive to heparin as well. In the present study we have begun to clarify the mechanisms underlying these regularly observed clinical findings.
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