Publications by authors named "C A Belmokhtar"
Article Synopsis
- Long-term adherence to chronic disease treatments is challenging, with only about 50% adherence in developed nations, prompting a need for effective management strategies.
- The study evaluated how satisfaction with the Flexig mHealth application influenced adherence to subcutaneous immunoglobulin therapy among French patients with chronic dysimmune diseases over two years.
- Results showed a high adherence rate of 99.7% linked to good user satisfaction with Flexig, indicating that digital tools can significantly enhance treatment compliance for patients.
Human fibrinogen concentrate (Fibryga) received temporary approval for fibrinogen replacement therapy in France (2017), with subsequent full approval for congenital and acquired hypofibrinogenemia. We evaluated real-world use for on-demand treatment of bleeding and prophylaxis to enhance our knowledge on fibrinogen concentrate as an option for fibrinogen replacement. Data were retrospectively collected from adult and pediatric patients with fibrinogen deficiency.
View Article and Find Full Text PDFIntroduction: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a debilitating autoimmune neuropathy that is treated with intravenous immunoglobulin (IVIG). The aim of this retrospective study was to investigate the efficacy and safety of the sucrose-free IVIG Octagam® (Octapharma AG, Lachen, Switzerland) in patients with CIDP.
Methods: Data from 47 patients who received at least one dose of Octagam were collected from the records of 11 centres in France.
The enzyme telomerase is involved in the replication of telomeres, specialized structures that cap and protect the ends of chromosomes. Its activity is required for maintenance of telomeres and for unlimited lifespan, a hallmark of cancer cells. Telomerase is overexpressed in the vast majority of human cancer cells and therefore represents an attractive target for therapy.
View Article and Find Full Text PDFInduction and execution of apoptosis programs are generally believed to be mediated through a hierarchy of caspase activation. By using two cellular variants obtained from the L1210 cell line (L1210/S and L1210/0), we have shown previously that staurosporine induces apoptotic cell death through both caspase-dependent and caspase-independent pathways. Both pathways normally coexisted in L1210/S cells, whereas L1210/0 cells lacked the ability to activate caspases despite the confirmed presence of both procaspase-3 and -9.
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