Publications by authors named "C A Arrigo"
The feature with Gene ID 108083276 was determined to be an ortholog of absent, small, or homeotic discs 1 ( ). Two isoforms, ash1-PB and ash1-PC, were constructed on the Muller D element using the GEP annotation protocol. The second coding exon of includes an insertion translated into 18 additional amino acids compared to the protein and is supported by RNA-Seq coverage, the lack of splice junction predictions, and multiple gene predictors.
View Article and Find Full Text PDFContext.—: Recently, a new type of antibody-drug conjugate, trastuzumab-deruxtecan (T-DXd), has been approved for the treatment of metastatic breast cancer with low level of human epidermal growth factor receptor 2 (HER2) gene expression. Thereby, eligibility relies on an accurate diagnosis of HER2-low status defined by immunohistochemistry IHC 1+/2+ with no gene amplification.
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- The feature with NCBI Gene ID 108084518 is identified as an ortholog of a member in the FlyBase High Mobility Group Box Transcription Factors gene group.
- Five isoforms were created using the GEP F element annotation method, with Sox102F-PNE being the longest and novel isoform based on specific RefSeq prediction and RNA-seq data.
- The longest isoform, Sox102F-PB, shows a 1.18x expansion in coding span due to the insertion of a transposable element in an intron, and all isoforms share the conserved HMG_box_dom domain.
The availability of more effective biological therapy can improve outcomes of gastric cancer (GC), but most patients do not have access to personalized treatment. GC molecular classification helps identify patients suitable for specific therapies and provides useful prognostic information. To date, only a small number of patients have access to molecular classification.
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