Publications by authors named "C A Alder"

Introduction: Single-stage bilateral cleft lip repair may require preoperative naso-alveolar molding (NAM) to decrease cleft widths and reposition the premaxilla. Staged operations may be performed in centers or regions without easy access to NAM. This retrospective study aims to examine the national prevalence of single-stage and staged bilateral cleft lip repairs over the past 23 years.

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Intraoperative assessment of labral quality determines arthroscopic repair versus reconstruction for hip labral tear treatment. T2 mapping technology discriminates between healthy and damaged cartilage. This study investigated if T2 mapping magnetic resonance imaging (MRI) can preoperatively predict labral repair versus reconstruction.

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Purpose: With the expansion of neonatal care in sub-Saharan Africa (SSA), an increasing number of premature babies are at risk to develop retinopathy of prematurity (ROP). Previous studies have quantified the cost-effectiveness of addressing ROP in middle-income countries, but few have focused on SSA. This study estimates the cost of a national program for ROP screening and anti-VEGF injection treatment in Rwanda compared to the status quo.

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Article Synopsis
  • Clinical metagenomics enhances the detection of microorganisms in clinical samples through genomic sequencing while minimizing human DNA interference, using a rapid mechanical method for simultaneous RNA and DNA analysis.
  • The method involves mechanically lysing human cells and employing nonspecific endonuclease to deplete human DNA, allowing the conversion of RNA to dsDNA for comprehensive sequencing.
  • Results indicate high sensitivity and specificity in identifying various pathogens, with a promising concordance with traditional testing methods, suggesting potential for routine use in microbiology labs with further validation.
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