Publications by authors named "C A Acevedo"
Article Synopsis
- The study explores how the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene affects the colonization of a specific harmful bacteria, AIEC, in the intestines, which is linked to inflammatory bowel disease (IBD).
- Researchers used genetically modified mice to compare the effects of AIEC and a non-invasive strain on intestinal bacteria levels, immune response, and barrier function.
- Results showed that mice lacking PTPN2 had greater AIEC colonization, lower levels of protective proteins, and increased intestinal permeability, highlighting the gene's critical role in maintaining gut health.
Unlabelled: The osteon is the primary structural component of bone, contributing significantly to its unique toughness and strength. Despite extensive research on osteonal structure, the properties of osteons have not been fully investigated, particularly within the context of bone fragility diseases like type 2 diabetes mellitus (T2DM). This study aims to isolate osteons from bovine bone, simulate the effects of increased advanced glycation end-products (AGEs) in T2DM through ribosylation, and evaluate the mechanical properties of isolated osteons.
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- - This study investigates the acute phase of Chagas disease in Colombia, focusing on cases from 2019 to fill a critical knowledge gap.
- - The research aims to improve understanding of the disease dynamics during this pivotal phase, especially in relation to oral transmission.
- - Findings will help enhance disease management strategies and public health responses to this neglected tropical disease in Colombia.
Mineral and cross-linking in collagen fibrils: The mechanical behavior of bone tissue at the nano-scale.
J Mech Behav Biomed Mater
November 2024
The mineralized collagen fibril is the main building block of hard tissues and it directly affects the macroscopic mechanics of biological tissues such as bone. The mechanical behavior of the fibril itself is determined by its structure: the content of collagen molecules, minerals, and cross-links, and the mechanical interactions and properties of these components. Advanced glycation end products (AGEs) form cross-links between tropocollagen molecules within the collagen fibril and are one important factor that is believed to have a major influence on the tissue.
View Article and Find Full Text PDFObesity can increase the risk of bone fragility, even when bone mass is intact. This fragility stems from poor bone quality, potentially caused by deficiencies in bone matrix material properties. However, cellular and molecular mechanisms leading to obesity-related bone fragility are not fully understood.
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