Crosstalk between fibroblasts and T cells in immune networks.

Fibroblasts are primarily considered as cells that support organ structures and are currently receiving attention for their roles in regulating immune responses in health and disease. Fibroblasts are assigned distinct phenotypes and functions in different organs owing to their diverse origins and functions. Their roles in the immune system are multifaceted, ranging from supporting homeostasis to inducing or suppressing inflammatory responses of immune cells.

Aquatic Exercise at Thermoneutral Water Temperature Enhances Antitumor Immune Responses.

Despite the broad rehabilitative potential of aquatic exercises, the relationship between aquatic exercise and the immune system has not been fully elucidated to date. In particular, there are few specific and delicate immunological approaches to the effect of water temperature on immunity. Thus, we examined the effect of water temperature on immunity during aquatic exercise.

Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses.

IL-17 produced by Th17 cells has been implicated in the pathogenesis of rheumatoid arthritis (RA). It is important to prevent the differentiation of Th17 cells in RA. Homodimeric soluble γc (sγc) impairs IL-2 signaling and enhances Th17 differentiation.

The Potential Role of a Soluble γ-Chain Cytokine Receptor as a Regulator of IL-7-Induced Lymphoproliferative Disorders.

IL-7 is an essential, nonredundant growth factor for T and B cell generation and maintenance. While IL-7 deficiency results in lymphopenia, overexpression of IL-7 can cause neoplasia in experimental models. IL-7's involvement in neoplasia has been appreciated through studies of IL-7 transgenic (Tg) mice models and human lymphoma patients.

Soluble γc receptor attenuates anti-tumor responses of CD8 T cells in T cell immunotherapy.

Previous studies have shown that soluble common γ-chain (sγc) modulates CD4 T cell immunity with antagonistic functions in γc cytokine signaling. However, the role of sγc in functional properties of effector CD8 T cells has not been fully defined. In this study, we report a new mechanism by which the anti-tumor activity of mouse CD8 T cells is suppressed in sγc of their own producing.

Soluble common gamma chain exacerbates COPD progress through the regulation of inflammatory T cell response in mice.

Cigarette smoking (CS) is a major cause of considerable morbidity and mortality by inducing lung cancer and COPD. COPD, a smoking-related disorder, is closely related to the alteration of immune system and inflammatory processes that are specifically mediated by T cells. Soluble common gamma chain (sγc) has recently been identified as a critical regulator of the development and differentiation of T cells.

IL-7 Induces an Epitope Masking of c Protein in IL-7 Receptor Signaling Complex.

IL-7 signaling via IL-7R and common -chain (c) is necessary for the development and homeostasis of T cells. Although the delicate mechanism in which IL-7R downregulation allows the homeostasis of T cell with limited IL-7 has been well known, the exact mechanism behind the interaction between IL-7R and c in the absence or presence of IL-7 remains unclear. Additionally, we are still uncertain as to how only IL-7R is separately downregulated by the binding of IL-7 from the IL-7R/c complex.

The role of soluble common gamma chain in autoimmune disease.

The common gamma chain (γc) is the central signaling unit for a number of cytokine receptors collectively known as the γc cytokine receptor family. γc is critical for ligand binding and signaling by γc cytokines. γc cytokine signaling had been thought to be mainly regulated by cytokine-specific receptor α chain expression levels with little or no effect by γc surface levels because γc expression was presumed to remain unchanged during T-cell activation and development.