Publications by authors named "Byung-Rok Je"
Article Synopsis
- Lysine-type peptidoglycan is recognized by the PGRP-SA protein, triggering two important immune pathways: Toll and prophenoloxidase, particularly in organisms like Drosophila and Tenebrio molitor.
- A specific fragment of this peptidoglycan, characterized as a long glycan chain with short stem peptides, enhances the activation of these immune pathways.
- Lysozyme plays a critical role by partially digesting the peptidoglycan, which increases PGRP-SA binding and ultimately leads to the activation of immune responses through the recruitment of other proteins.
Melanin synthesis is essential for defense and development but must be tightly controlled because systemic hyperactivation of the prophenoloxidase and excessive melanin synthesis are deleterious to the hosts. The melanization cascade of the arthropods can be activated by bacterial lysine-peptidoglycan (PGN), diaminopimelic acid (DAP)-PGN, or fungal beta-1,3-glucan. The molecular mechanism of how DAP- or Lys-PGN induces melanin synthesis and which molecules are involved in distinguishing these PGNs are not known.
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