Publications by authors named "Byung-Ho Son"
We investigated the safety and performance of the Da Vinci SP single-port robot (SP robot) in nipple-sparing mastectomy (NSM) with immediate reconstruction. Medical records of 60 women aged ≥ 19 years who had undergone SP robot-assisted unilateral or bilateral NSM with immediate reconstruction between October 2020 and August 2021 were retrospectively analyzed. Stage I (31, 47.
View Article and Find Full Text PDFIn breast-conserving surgery (BCS), clear resection margins are crucial to prevent recurrence. Accurate imaging is vital for precise BCS, with MRI being the most accurate. However, MRI has limitations in identifying the exact extent of breast cancer in patients who have undergone neoadjuvant chemotherapy (NACT).
View Article and Find Full Text PDFAim: To compare menopausal symptoms between tamoxifen alone and tamoxifen with ovarian function suppression (OFS) over 12 months, identifying related factors.
Methods: This prospective, observational study included 209 premenopausal patients with breast cancer on tamoxifen, recruited from Asan Medical Center, Republic of Korea. We collected demographic and clinical information from the participants' medical records and assessed menopausal symptoms using the Korean Menopause Rating Scale (MRS) at 3-, 6-, and 12-months postdiagnosis.
Fluorescence-guided surgery has emerged as an innovative technique with promising applications in the treatment of various tumors, including colon cancer. Tumor-initiating probe yellow (TiY) has been discovered for identifying tumorigenic cells by unbiased phenotypic screening with thousands of diversity-oriented fluorescence library (DOFL) compounds in a patient-derived lung cancer cell model. This study demonstrated the clinical feasibility of TiY for tumor-specific fluorescence imaging in the tissues of patients with colorectal cancer (CRC).
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- The study evaluated the effectiveness of 18F-FES PET/CT imaging in detecting distant metastasis or recurrence in patients with estrogen receptor-positive (ER-positive) breast cancer.
- It analyzed data from 162 patients and found that 18F-FES PET/CT had a high sensitivity (95%) and specificity (89%) for diagnosing these conditions, outperforming standard imaging methods.
- The researchers concluded that 18F-FES PET/CT is a valuable tool for accurately diagnosing ER-positive breast cancer patients who may have metastasis or recurrence.
The clinical impact of 16α-F-fluoro-17β-estradiol (F-FES) PET/CT on patient management has not been well investigated. The aim of this study was to assess the clinical impact of F-FES PET/CT on the management of patients with recurrent or metastatic breast cancer. Study subjects were identified retrospectively from a database of a prospective trial for postmarketing surveillance of F-FES between 2021 and 2023.
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- The study focused on treatment results and failure patterns in breast cancer patients classified as cT3N0 who underwent neoadjuvant chemotherapy (NAC) followed by surgery.
- Researchers examined 87 patients from 2000 to 2015, identifying high-risk individuals based on specific clinical factors like age and tumor characteristics.
- Results showed promising outcomes overall, with low rates of recurrence; however, high-risk patients faced significantly worse outcomes, highlighting the importance of pre-treatment evaluation for predicting survival.
The prevalence and dynamics of circulating tumor DNA (ctDNA) in patients with breast cancer recurrence or de novo metastatic cancer were examined in a retrospective analysis of a prospective observational cohort. Twenty-three recurrent/metastatic breast cancer cases (8 locoregional, 15 distant metastasis) were enrolled, and sequential plasma samples were obtained. Anchor mutations were selected from the target sequencing of each patient's primary and/or metastatic tumor.
View Article and Find Full Text PDFPurpose: This research aimed to clarify the impact of residual ductal carcinoma in situ(DCIS) in surgical specimens obtained after neoadjuvant chemotherapy(NAC) for breast cancer on the associated prognosis outcomes.
Methods: This retrospective study was performed on a cohort of 1,009 patients who achieved pCR following NAC for breast cancer and underwent subsequent breast surgery at a single institution between January 2008 and December 2019. Overall survival, local recurrence-free survival, distant metastasis-free survival, and disease-free survival of the residual and non-residual DCIS groups were the outcomes compared, with further subgroup analysis performed according to hormone receptor status.
Introduction: Male breast cancer (MBC) is a rare condition, and recent research has underscored notable distinctions between MBC and breast cancer in women. This study aimed to assess and contrast the long-term survival outcomes and disease patterns of MBC patients with those of their female counterparts.
Methods: We analyzed data from 113,845 patients diagnosed with breast cancer who had undergone curative surgery from the Korean Breast Cancer Registry (KBCR) between January 1990 and August 2014 in Seoul, Korea.
Purpose: Tumescent in nipple-sparing mastectomy (NSM) has been reported to increase the risk of necrosis by impairing blood flow to the skin flap and nipple-areolar complex. At our institution, we introduced a tumescent-free robotic NSM using the da Vinci single-port system (Intuitive Surgical, Inc.).
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- The study aimed to identify patients with microinvasive breast cancer (MIBC) who would benefit from sentinel lymph node biopsy (SLNB) by analyzing the characteristics and risk factors for axillary lymph node metastasis (ALNM).
- Out of 1688 MIBC patients who underwent surgery, 83.5% had only SLNB, with only 4.1% found to be node-positive, mostly with small micro-metastases.
- The results highlighted specific risk factors like young age, presence of lymphovascular invasion, and hormone receptor positivity as predictors for ALNM, suggesting routine SLNB may not be necessary but could be beneficial for those with these risk factors.
Purpose: This study aimed to investigate the frequency of BRCA testing and related factors among young breast cancer patients (age < 40 years) in South Korea.
Materials And Methods: We conducted a nationwide retrospective cohort study using data from the Health Insurance Review and Assessment claims. Newly diagnosed breast cancer patients younger than 40 were included.
Purpose: To compare the oncological safety of nipple-sparing breast-conserving surgery (BCS) versus central lumpectomy for centrally located breast cancer (CLBC).
Methods: Patients who underwent BCS for CLBC at Asan Medical Center from 2007 to 2018 were reviewed retrospectively. The oncological outcomes of nipple-sparing BCS (NS-BCS) and central lumpectomy were compared using univariate and multivariate Cox regression analyses and compared again after 1:1 propensity score matching (PSM).
Article Synopsis
- - The study aimed to evaluate the effectiveness of abdominal staging CT scans in finding liver metastasis in breast cancer patients initially diagnosed, analyzing a large cohort of 2056 patients over a two-year period.
- - The diagnostic yield (DY) was found to be low overall at 1.1%, but it significantly increased in patients with stage III cancer (3.9%) and in those with HER2-enriched cancers, suggesting certain groups may benefit more from this imaging technique.
- - Although the findings indicate that routine abdominal staging CT scans may not be necessary for all breast cancer patients, they are recommended for those with more advanced disease or specific cancer subtypes.
Importance: Young patients with breast cancer have higher risk for developing contralateral breast cancer (CBC) and have epidemiologic characteristics different from those of older patients.
Objective: To examine the incidence and peak occurrence of CBC according to age at primary breast cancer (PBC) surgery.
Design, Setting, And Participants: This cohort study included patients who were diagnosed with and underwent surgery for unilateral nonmetastatic breast cancer at Asan Medical Center, Korea, between January 1, 1999, and December 31, 2013, with follow-up through December 31, 2018.
Article Synopsis
- A study was conducted in Seoul, South Korea, involving mothers with stage 0 to 3 breast cancer to understand the impact of the disease on their parenting stress and their children's emotional development.
- It was found that mothers with children experienced higher rates of depression, especially those undergoing specific treatments, while the duration of their illness was linked to lower depression levels.
- The results highlighted factors such as caring for older children and being the primary caregiver that influenced parenting stress, indicating that these women face significant emotional challenges alongside their health issues.
Background: In this study, the authors compared conventional and robot-assisted mastectomy and breast reconstruction. To the authors' knowledge, this study is the first to report the results of robot-assisted mastectomy and breast reconstruction and provide a comparison of patient-reported outcomes.
Method: This retrospective study included 473 breasts of 423 patients who underwent conventional mastectomy and breast reconstruction and 164 breasts of 153 patients who underwent robot-assisted mastectomy and breast reconstruction from July of 2019 to October of 2021.
Importance: The disparate prognostic implications between invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) have been demonstrated. However, information on premenopausal patients remains insufficient.
Objective: To examine long-term survival outcomes of ILC and IDC in premenopausal patients using national databases.
Article Synopsis
- The study investigates the effectiveness of sentinel lymph node biopsy (SLNB) compared to axillary lymph node dissection (ALND) in breast cancer patients who showed a clinical complete response in the axilla after neoadjuvant chemotherapy.
- In the analysis of 902 patients, the axillary recurrence rate (ARR) was similar between the SLNB (3.2%) and ALND (1.8%) groups, with significantly worse disease-free survival (DFS) and overall survival (OS) in the ALND group.
- The results suggest that cN1 breast cancer patients who convert to ypN0 after treatment may safely be managed with SLNB alone, indicating a potential shift in standard care practices.
The prognostic role of the recurrence score (RS) based on the 21-gene expression assay in premenopausal women is not well delineated, and we investigated the association of outcomes and the RS in premenopausal patients who had 21-gene expression assay at Asan Medical Center, Seoul, Korea, between June 2005 and July 2018. Invasive breast cancer-free survival (IBCFS) by STEEP version 2.0 was compared according to the RS and clinical risk factors.
View Article and Find Full Text PDFImportance: Contralateral breast cancer (CBC) is the most frequently diagnosed primary cancer in patients with breast cancer. Although many studies have reported survival after the development of CBC, results have been inconsistent.
Objective: To investigate whether the development of CBC is associated with survival among patients with breast cancer.
Article Synopsis
- High 21-gene recurrence score (RS) and high Ki-67 levels are both poor prognostic factors in estrogen receptor-positive (ER+) breast cancer, though their relationship and impact on survival are not fully understood.
- This study examined 2,295 women with ER+/ERBB2- breast cancer to investigate the relationship between RS, Ki-67 expression, and recurrence-free survival (RFS), with a focus on those with low RS.
- Results indicated a moderate correlation between RS and Ki-67 levels, with significant differences in RFS observed based on Ki-67 levels among patients with low RS.
Purpose: Considering prognostic and anatomic stages in early-stage premenopausal patients with breast cancer, clinicians decide on performing the multigene assay, adjuvant chemotherapy, or ovarian function suppression (OFS). This decision is also based on genetic information related to hormone receptor-positive and human epidermal growth factor receptor 2 negative results. We aimed to determine the tendency to use adjuvant therapy in clinical practice.
View Article and Find Full Text PDFPurpose: This study aimed to analyze the waiting time for initial treatment after breast cancer diagnosis and determine the factors influencing treatment delay in South Korea.
Methods: This nationwide retrospective cohort study was conducted using the Health Insurance Review and Assessment data. The participants were classified according to the regions where their biopsy and treatment were performed (Seoul-Seoul, Metro-Metro, Other-Other, Metro-Seoul, Other-Seoul).