The Role of TRP Channels in Sepsis and Colitis.

To date, several members of the transient receptor potential (TRP) channels which provide a wide array of roles have been found in the gastrointestinal tract (GI). The goal of earlier research was to comprehend the intricate signaling cascades that contribute to TRP channel activation as well as how these receptors' activity affects other systems. Moreover, there is a large volume of published studies describing the role of TRP channels in a number of pathological disorders, including inflammatory bowel disease (IBD) and sepsis.

Inactivating and damaging properties of the disinfectant "MultiDez" when exposed to bacteria and spores.

Disinfectants play a crucial role in controlling the spread of infectious diseases caused by bacteria and spore-forming organisms. Bacteria and spores can persist on surfaces and in the environment for extended periods, posing a significant risk to public health. Disinfectants are designed to inactivate or kill these microorganisms by disrupting their cellular structures and functions.

Inflammatory Bowel Disease: Crosstalk between Histamine, Immunity, and Disease.

Inflammatory bowel disease (IBD) is increasingly recognized as a serious, worldwide public health concern. It is generally acknowledged that a variety of factors play a role in the pathogenesis of this group of chronic inflammatory diseases. The diversity of molecular actors involved in IBD does not allow us to fully assess the causal relationships existing in such interactions.

Hypoxia and Intestinal Inflammation: Common Molecular Mechanisms and Signaling Pathways.

The gastrointestinal tract (GI) has a unique oxygenation profile. It should be noted that the state of hypoxia can be characteristic of both normal and pathological conditions. Hypoxia-inducible factors (HIF) play a key role in mediating the response to hypoxia, and they are tightly regulated by a group of enzymes called HIF prolyl hydroxylases (PHD).

Polymorphism of toll-like receptor genes and autoimmune endocrine diseases.

In recent years, there has been a significant amount of interest and vigorous studies on mutations related to innate immunity receptor genes such as Toll-like receptors (TLR), which is driven by the identification of many associations between these mutations and development of various disorders leading, in particular, to autoimmune diseases. It has been proven that the occurrence of single nucleotide polymorphisms in DNA sequences encoding TLRs causes malfunction of some key signaling pathways, and, as a result, increases the risk of autoimmune diseases. The identification of these polymorphisms can lead to the understanding of the pathogenesis of autoimmune diseases, which subsequently will create effective methods for the prevention and treatment thereof.

Global analysis of an exponential model of cell proliferation for estimation of cell cycle duration in the root apical meristem of angiosperms.

Background And Aims: Information on cell cycle duration (T) in the root apical meristem (RAM) provides insight into root growth, development and evolution. We have previously proposed a simple method for evaluating T based on the dynamics of root growth (V), the number of cells in the RAM (Nm) and the length of fully elongated cells (l), which we named the rate-of-cell-production (RCP) method. Here, a global analysis was performed to confirm the reliability of this method in a range of angiosperm species and to assess the advantages of this approach.

[Length of Meristematic and Fully Elongated Root Cells Related to Haploid DNA Content].

The lengths of meristematic (l(m)) and fully-elongated cells (l(e)) were measured in the roots of 118 monocot and dicot species of herbaceous plants from 20 angiosperm families. The results were analyzed using the data on haploid DNA content (C(val)) for the same species from the website (http://data.kew.

Expression of Pattern Recognition Receptors by Nociceptive Metasympathetic Neurons.

Immunohistochemical assay with double label and confocal laser scanning microscopy showed that innate immunity receptor TLR4 is expressed predominantly in neurons of the intestinal Auerbach (myenteric) plexus, while vanilloid nociceptive receptor TRPV1 is expressed by neurons of Meissner (submucous) plexus. Immunohistochemical analysis with triple labeling revealed coexpression of TLR4 and TRPV1 in enteric neurons of rat colon. The results attest to a possibility of functional interaction between Toll-like and vanilloid receptors in the neuron level.

[The role of ethylene in activation division cell quiescent center in the cut maize roots].

In the present work we used two maize cultivars in which root meristem responded differently to root tip excision: in Interkras-375 MW we observed meristem opening due to the activation of cell divisions in the quiescent center (QC), while in Krasnodar-194 MW the meristem remained closed. Excised root tips of Interkras M B-375 were shown to produce much more ethylene than excised root tips of Krasnodar-194 MW The inhibitor of ethylene biosynthesis L-α-ethoxyvinyl 2amino-glycine-HCl (AVG) and inhibitors of ethylene action AgNO3 and 1-methyl-cyclopropene (MCP) prevented meristem opening in excised root tips of Intekras-375 MW. The obtained results allow us to conclude that ethylene plays an important role in the activation of cell divisions in the QC of excised root tips.

[Age-dependent changes of neurochemical properties of sensory neurons].

Sensory neurons represent various groups of neurons differ on their morphological, immunohistochemical and receptor characteristics. The most of large neurons with myelinated Adelta fibers contain neurofilament 200 kD (NF200), some small afferent neurons can bind the isolectin B4 (IB4). Also, sensory neurons may include different types of tyrosine kinases (trkA, B and C) and neurotransmitters.

[Activation of cell division in the quiescent center of excised maize root tip].

The phenomenon of activation of cell proliferation in the quiescent center of excised maize roots is described. The root tips were grown on wet filter paper in Petri dishes. This phenomenon was observed in 8 to 14 maize cultivars and was absent in excised Arabidopsis root tips.

[Analysis of possible mechanisms of regulation of root branching].

The formation of lateral roots under the influence of growth inhibitors and phytohormons were studied with germs of corn and flax. All corn primordiums develop into the lateral roots without dormancy period, while some flax primordiums are delayed in development. Removal of root apical meristem (decapitation) does not result in the increase in number of lateral roots of corn germs.

[Microfungicid--a preparation based on trichoderma viride for plant diseases control].

A technology was designed for manufacturing a preparation based on Trichoderma viride Pers ex S.F. Gray that strongly suppresses the development of causative agents of certain plant diseases and displays a growth-stimulating activity.

[A model for the formation of ring-shaped structures in colonies of mycelial fungi].

Mathematical model of the development of the pattern of colonies is considered. The model represents the systems of differential equations of the first order. It includes non-dimensional parameters characterizing the following features: concentration of substrate, concentration of metabolic products--growth inhibitor, mycelium and spores, radial and specific rate of mycelium growth, rate of substrate consumption and production of metabolic products, coefficients of diffusion of substrate and metabolic products, initial concentration of mycelium and substrate, time of delay of mycelium reaction on metabolic products and spore formation, threshold concentration of metabolic products.

[Dependence of biological activity of triamine type platinum (II) complexes on their composition and structure].

The growth-inhibiting effect on the roots of maize and cucumber shoots was studied. We tested 53 triamine complexes of platinum (cis*- and trans*-[Pt(NH3)*2LCl]Cl, cis*- and trans*-[PtHx*2LCl]Cl and [PtenLCl]Cl, where Hx is hydroxylamine, en is ethylenediamine, and L are various heterocycles, which either have biological activity and occur in the cells or have no biological activity and are foreign to the cells). The cis*-[Pt(NH3)*2LCl]Cl and [PtenLCl]Cl complexes showed cytostatic properties, and the latter were effective at higher concentrations.

[The growth-inhibiting activity of mixed complexes of platinum(II) with ammonia and cycloalkylamines].

The effect was studied of mixed cys- and 3-, 4-, 5-, 6-nomial cycloalkylamines or substituted 2-, 3-, 4-methyl- and 4-hydroxycyclohexylamines as well as similar carboxylatocomplexes containing anions of malonic hydroxymalonic, succinic and malic acids on the growth of corn sprout roots. Complexes with non-substituted cycloalkylamines possessed the most pronounced cytostatic activity. Complexes with substituted cyclohexylamines were less active than their non-substituted analogue as well as other complexes with lesser size of cyclic substitute.

[Antiviral activity of ribamidyl in experimental infections with California encephalitis group viruses].

A preparation of ribamydil, an analogue of natural nucleosides, synthesized at the Latvian SSR Institute of Organic Chemistry showed a sufficiently high activity against bunyaviruses of California encephalitis complex both in vitro and in vivo. Various modifications of the enzyme immunoassay may be used for control of the effectiveness of treatment with this drug. Some advantages of the subcutaneous route over the intramuscular one were found.