Publications by authors named "Byoungin Lee"
Human iPSC-derived retinal organoids develop robust Alzheimer's disease neuropathology.
Front Cell Neurosci
January 2024
Article Synopsis
- Alzheimer's disease (AD) affects about 50 million people globally and is marked by memory loss, cognitive decline, and brain features like amyloid beta plaques and phosphorylated Tau proteins.
- Recent studies suggest that similar histopathological signs of AD can be found in the retina, indicating its potential as a non-invasive diagnostic tool for early detection of the disease.
- The researchers created a novel retinal organoid model using induced pluripotent stem cells from familial AD patients, revealing that while these organoids are similar in cellular makeup to healthy ones, they show increased levels of amyloid beta and Tau proteins, paving the way for drug testing and biomarker research.