Publications by authors named "Byong-Sop Lee"
Objectives: This study explored how group-based early parent education impacts development in preterm infants.
Methods: This retrospective cohort study, with a historical control group, included preterm infants (n = 246) with corrected ages (CAs) of 0-3 months. Those visiting the clinic between July 2017 and December 2018 formed the control group (n = 145), whereas those visiting between January 2019 and February 2020 (n = 101) constituted the education group.
Background: Extracorporeal membrane oxygenation (ECMO) is the only treatment option that can stabilize patients with congenital diaphragmatic hernia (CDH) with severe pulmonary hypertension. This study assessed the effects of a multidisciplinary ECMO team approach (META) as part of a quality improvement initiative aimed at enhancing the survival rates of neonates with CDH.
Methods: The medical records of infants with CDH treated at a tertiary center were retrospectively reviewed.
Background: Very low birth weight infants (VLBWIs) continue to face high mortality risk influenced by the care quality of neonatal intensive care units (NICUs). Under-standing the impact of workload and regional differences on these rates is crucial for improving outcomes.
Purpose: This study aimed to assess how the structural and staffing attributes of NICUs influence the mortality rates of VLBWIs, emphasizing the significance of the availability of medical personnel and the regional distribution of care facilities.
Bronchopulmonary dysplasia (BPD) is a serious chronic lung disease affecting extremely preterm infants. While mitochondrial dysfunction has been investigated in various medical conditions, limited research has explored mitochondrial DNA (mtDNA) gene mutations, specifically in BPD. This study aimed to evaluate mitochondrial mtDNA gene mutations in extremely preterm infants with BPD.
View Article and Find Full Text PDFBackground: Right-sided congenital diaphragmatic hernia (RCDH) is a rare and often fatal congenital anomaly, primarily attributed to lung hypoplasia, which is associated with small branch pulmonary artery (PA). This study investigated whether postnatal PA measurements obtained through echocardiography are associated with mortality or the extracorporeal membrane oxygenation (ECMO) requirement in neonates with RCDH.
Methods: A retrospective study was conducted on neonates with RCDH born between 2008 and 2022.
Introduction: This study aimed to investigate the outcomes of infants at 18-24 months born in the Korean Neonatal Network with a birth weight <500 g.
Methods: The anthropometric and neurodevelopmental data of infants with a birth weight <500 g at a gestational age of ≥22 weeks who were registered in the Korean Neonatal Network 2013-2017 and followed up at a corrected age of 18-24 months were reviewed. Neurodevelopmental impairment was defined as the presence of any of the following: (1) cerebral palsy; (2) severe visual impairment; (3) hearing impairment; or (4) cognitive impairment.
Background: To predict whether the left pulmonary artery (LPA) to the main pulmonary artery (MPA) ratio measured by echocardiography in left congenital diaphragmatic hernia (CDH) was related to death or need for extracorporeal membrane oxygenation (ECMO).
Methods: This retrospective study analyzed neonates with left CDH born between 2018 and 2022 in a single tertiary medical institution. Echocardiography was performed immediately after birth.
Article Synopsis
- MIRAGE syndrome is a rare disease that can cause growth problems, infections, and issues with adrenal glands and digestion.
- A baby girl with this syndrome was born very early and weighed only 656 grams, facing many health challenges such as trouble breathing and low hormone levels.
- Despite getting treatment, she had ongoing problems like chronic diarrhea and slow growth, but she was eventually sent home with special feeding methods.
Article Synopsis
- Biliary atresia is a serious bile duct condition in newborns that requires quick diagnosis and surgical treatment; this study aimed to create a machine learning model to improve detection of the condition.
- Researchers analyzed data from over 1,600 newborns with cholestasis and found that specific lab results and imaging tests were key indicators; they used the XGBoost machine learning framework to develop models with high accuracy in predicting biliary atresia.
- The new predictive models were validated with high performance scores and were integrated into a web-based tool to assist in clinical settings, making this one of the largest studies focused on neonatal cholestasis detection.
Background: The aim of the study was to determine the rate of cytomegalovirus virolactia in the human milk (HM) of mothers of VLBW infants, compare the CMV infection rates and the changes in CMV DNA viral load and nutrient profile among different HM preparation methods.
Methods: A prospective randomized controlled study was performed in infants with gestational age < 32 weeks or birth-weight < 1500 g admitted to neonatal intensive care unit of Asan Medical Center and Haeundae Paik Hospital who were given mother's own milk. Enrolled infants were randomized into three groups according to the HM preparation methods: freezing-thawing (FT), FT + low-temperature Holder pasteurization (FT + LP), and FT + high-temperature short-term pasteurization (FT + HP).
Objective: To evaluate associations between postnatal imaging features and outcome of left-sided congenital diaphragmatic hernia, as defined by overall survival and a requirement for extracorporeal membrane oxygenation (ECMO).
Study Design: Newborns diagnosed prenatally with left-sided congenital diaphragmatic hernia between January 2013 and September 2021 were studied retrospectively. The esophageal deviation index was newly defined as the largest diameter from the midline to deviated gastric tube divided by the largest transverse diameter of the thoracic cavity on the radiograph.
Article Synopsis
- The study researched the causes and outcomes of neonatal cholestasis in a hospital, aiming to create a model to predict mortality in affected infants.
- Researchers analyzed data from 4028 infants, finding that conditions like prematurity and congenital heart anomalies were leading causes, with a 9.9% mortality rate within the first year.
- A prediction model based on simple lab tests demonstrated strong performance in predicting mortality, validated by external data from other hospitals, indicating its potential clinical utility.
Article Synopsis
- A 900g baby boy was born really early at 27 weeks and had to use a special breathing machine for a long time until his surgery at 39 days old.
- He had surgery to fix a hole in his diaphragm and was able to go home 36 days after that, still needing a little help to breathe.
- The study shows that babies born very early with this problem might have different health outcomes than full-term babies, and researchers should look into this more.
Article Synopsis
- There are more babies being born early or small, which leads to more cases of a serious infection called neonatal sepsis.
- Researchers looked at data from a hospital over 20 years to see how common certain germs are and how effective treatments are against them.
- They found that the most common germs causing sepsis were different in babies born early and later, and that being born early or having certain germs made it more likely for babies to get really sick or die from sepsis.
Article Synopsis
- Right-sided congenital diaphragmatic hernia (RCDH) is less common than the left-sided variant, and there's limited clinical data on predicting neonatal outcomes based on antenatal assessments.
- A study reviewed the medical records of newborns with isolated RCDH, finding that a higher observed-to-expected lung area-to-head circumference ratio (O/E LHR) is associated with increased survival rates and reduced ECMO requirements.
- The research suggests that O/E LHR could serve as a reliable prognostic tool for understanding the severity and expected outcomes for RCDH, though further large-scale studies are needed to confirm these findings.
Background: This study aimed to investigate the survival and morbidities of infants in the Korean Neonatal Network (KNN) with birth weight (BW) < 500 g.
Methods: The demographic and clinical data of 208 live-born infants with a BW < 500 g at a gestational age of ≥ 22 weeks who were treated in the neonatal intensive care units of the KNN between 2013 and 2017 were reviewed.
Results: The survival rate of the infants was 28%, with a median gestational age and BW of 24 weeks (range, 22-33) and 440 g (range, 220-499), respectively.
We previously demonstrated the safety and feasibility of mesenchymal stem cell (MSC) transplantation for bronchopulmonary dysplasia (BPD) in preterm infants in a phase I clinical trial. We thus investigated the therapeutic efficacy of MSCs for BPD in premature infants. A phase II double-blind, randomized, placebo-controlled clinical trial was conducted on preterm infants at 23 to 28 gestational weeks (GW) receiving mechanical ventilator support with respiratory deterioration between postnatal days 5 and 14.
View Article and Find Full Text PDFPurpose: The agreement between axillary temperature (AT) and rectal temperature (RT) measurements has not been well established in preterm infants. Therefore, our study aimed to evaluate the agreement between AT and RT measurements in very preterm infants.
Methods: Preterm infants <32 weeks of gestational age were prospectively included.
Background: To evaluate the long-term functional and structural pulmonary development in children with repaired congenital diaphragmatic hernia (CDH) and to identify the associated perinatal-neonatal risk factors.
Methods: Children with repaired CDH through corrective surgery who were born at gestational age ≥ 35 weeks were included in this analysis. Those who were followed for at least 5 years were subjected to spirometry and chest computed tomography for evaluation of their functional and structural growth.
Objective: To report our experience with management of fetuses with congenital high airway obstruction syndrome (CHAOS).
Methods: We retrospectively reviewed the cases of fetuses who were prenatally diagnosed and postnatally confirmed with CHAOS between 2010 and 2019 at Asan Medical Center, Seoul, Korea.
Results: Of 13 fetuses prenatally diagnosed with CHAOS, 7 were lost to follow-up and 6 were postnatally confirmed as having CHAOS.
Background And Objectives: This study aimed to provide morbidity and mortality information on very low birth weight (VLBW) infants with congenital heart disease (CHD-VLBWs).
Methods: The study used a 10-year cohort of VLBW infants from a single institution. CHD was classified according to International Classification of Diseases, Version 9, Clinical Modification.
Background: Peritoneal dialysis (PD) has been used occasionally in extremely-low-birth-weight (ELBW) infants with acute kidney injury (AKI). This study aimed to evaluate the clinical characteristics and outcomes of ELBW infants with AKI treated with PD.
Methods: In this retrospective cohort study, the medical records of ELBW infants with AKI, who underwent PD from January 2008 to February 2018, were reviewed.
Background: Management of newborn infants with congenital anomalies is challenging and requires a multidisciplinary approach. The prevalence of congenital anomalies in very-low-birth-weight infants (VLBWIs; birth weight <1,500 g) has been rarely reported.
Objectives: The aim of this study was to investigate the epidemiology of congenital anomalies in VLBWIs and the association with early mortality and major morbidities.
Background: Hyperpolarized 13C spectroscopic magnetic resonance spectroscopy (MRS) is an advanced imaging tool that may provide important real-time information about brain metabolism.
Methods: Mice underwent unilateral hypoxia-ischemia (HI) on postnatal day (P)10. Injured and sham mice were scanned at P10, P17, and P31.