Modified neck dissection. A study of 967 cases from 1970 to 1980.

The medical records of 967 patients treated with a modified neck dissection were carefully reviewed, and the data were collected and statistically analyzed. For a primary tumor in the oral cavity or oropharynx, a supraomohyoid neck dissection was adequate treatment for the neck that was both clinically staged N0 or N1 and pathologically staged N1 without evidence of extracapsular invasion. For primary tumors in the larynx and hypopharynx, an elective bilateral anterior neck dissection is considered proper treatment if the nodes are not multiple or if connective tissue disease is not present.

The acquired immunodeficiency syndrome in a cohort of homosexual men. A six-year follow-up study.

A cohort of 6875 homosexual men, initially seen at the San Francisco City Clinic between 1978 and 1980, were studied to determine the incidence and prevalence of the acquired immunodeficiency syndrome, related conditions, and infection with the human T-lymphotropic virus, type III/lymphadenopathy-associated virus (HTLV-III/LAV). By December 1984, 2.4% of the men had the syndrome; mortality attributable to the syndrome in 1984 was 600/100 000.

Metastases to the larynx.

Eleven cases of metastases to the intrinsic larynx are reported. This number constitutes the largest collection from a single institution in the literature and brings the total recorded cases to 83. Cutaneous melanomas are the preponderant primaries, followed by renal cell carcinomas, and carcinomas of the breast and lung, respectively.

Multiple primary cancer risk in patients with major salivary gland carcinoma.

The subsequent primary cancer experience of 498 patients with major salivary gland carcinoma was evaluated using a life-table approach. Expected numbers were generated from two sources. These were population-based tumor registry data and an internal comparison group of randomly selected individually matched patients drawn from the same institution.

Treatment of choice for squamous carcinoma of the tonsillar fossa.

The records of 160 patients with squamous cell carcinoma of the tonsillar fossa treated from 1968 through 1979 were reviewed. Biologic behavior, local and regional findings, and other prognostic factors were evaluated. patients were treated by either radiation alone (112 patients), radiation followed by planned neck dissection (31 patients), surgery alone (11 patients), or surgery combined with radiation (6 patients).

Treatment of squamous carcinoma of the retromolar trigone.

Since squamous carcinoma of the retromolar trigone is unusual, there is a paucity of information in the world's literature to use as a reference for selecting treatment and determining pertinent factors affecting prognosis. Consequently, an analysis of the medical records of 110 patients with biopsy proven squamous carcinoma originating in the retromolar trigone, seen and treated entirely at The University of Texas M.D.

Effects of hypoxia on tissue capillarity in geese.

Tissue capillarity in the gastrocnemius and myoglobin concentrations in the gastrocnemius and heart were determined for hatchling Canada geese, Branta canadensis, following incubation of the embryos under either normoxic (Po2 = 120 torr) or hypoxic (Po2 = 94 torr) conditions. Similar observations were made on a limited number of hatchling bar-headed geese, Anser indicus, a species native to high altitude. Capillary densities were higher and diffusion distances shorter in the hypoxic Canada geese and the bar-headed geese than in the normoxic Canada geese.

Effects of maturation on tissue capillarity in chickens.

Tissue capillarity, diffusion distances and myoglobin concentrations in the anterior latissimus dorsi (ALD), consisting entirely of slow tonic fibers, the posterior latissimus dorsi (PLD), consisting entirely of twitch fibers, and the gastrocnemius (GST), consisting of both twitch and tonic fibers, were determined for the domestic chicken throughout maturation. Increases in muscle mass for the three muscles are due to fiber hypertrophy and are quantified as changes in the average cross-sectional area (FCSA) of the fibers. Capillary densities were highest in the newly hatched chicks: ALD = 3967 +/- 888 caps/mm2, PLD = 8360 +/- 1078 caps/mm2, and GST = 8360 +/- 8360 +/- 1283 caps/mm2; and decreased in proportion to the increase in FCSA, to adult values of ALD = 450 +/- 50, PLD = 120 +/- 20 and GST = 267 +/- 33 caps/mm2.

Malignant parotid tumors in patients under 20 years of age.

Since 1944, 26 patients with parotid cancer who were under 20 years of age have been seen and treated at the University of Texas M.D. Anderson Hospital and Tumor Institute at Houston by a single group of surgeons with a similar therapeutic approach.

Squamous carcinoma of the external ear.

The medical records of 486 patients with pathologically proved squamous carcinoma of the skin of the external ear were analyzed. It is a disease of elderly white men, and the helix is the most common site of origin. Well-differentiated squamous carcinoma is the most frequent histologic variant.

Results of surgery alone and surgery combined with postoperative radiotherapy in the treatment of cancer of the parotid gland.

Seventy-seven patients with primary malignant parotid tumors were studied and the various factors relative to their disease, as well as their treatment, were analyzed. Because of the retrospective nature of this study, no attempt was made to compare surgery alone with surgery and postoperative radiation, but it was interesting to reflect on the relative and absolute indications for the use of combined treatment versus surgery alone. The above-clavicle control in this group of patients was excellent, and the relatively low incidence of distant metastases reflect that optimal local control was closely correlated with survival.

Adenocarcinomas of the oral cavity: a clinicopathologic study of terminal duct carcinomas.

A clinico-pathologic study of 12 patients, each harboring a hitherto not delineated adenocarcinoma of salivary origin is presented. The authors have designated this histologically unique carcinoma as 'terminal duct adenocarcinoma' in deference not only to its light-optic appearance, but also to a putative origin from the reserve cells (epithelial and myoepithelial) of the intercalated duct. The tumors' local invasive properties with extension into nerves and adjacent bone suggest their biologic behavior is like that of adenoid cystic carcinomas.

Clinical effects of closed suction drainage on wound healing in patients with head and neck cancer.

This study was undertaken to determine what optimal levels of suction pressure were necessary to provide good drainage volume and obliteration of any dead space and also to determine the prevalence of clotting and complications secondary to various levels of suction pressure. The patients were grouped by their degree of nutritional depletion, prior radiation exposure, the types of surgical procedures undergone, and the results of tests using four levels of suction pressure. Three of the suction pressure values were obtained with a wall suction and one was obtained using a portable closed system.

Squamous carcinoma of the larynx in patients under the age of 35 years.

Laryngeal carcinoma usually occurs in men between the ages of 50 and 70. In general, epithelial malignancies other than those involving the skin are rare in the young adult. Those squamous carcinomas arising in the lip, tongue, and tonsil appear to have a poorer prognosis than in the older adult.

Cost-effectiveness in eyebanking.

The current operating budget for American eyebanks is more than $5 million per year, and an increasing portion of this expense is being paid by third-party payers. American eyebanks were surveyed to determine what a reasonable cost per transplant tissue might be and to see if recommendations could be made that would help optimize cost-effectiveness in American eyebanking. Most well-run eyebanks needed between $222 to $464 to process each donor cornea for transplantation.

Malignant melanoma of the skin of the nose.

Seventeen patients with cutaneous melanomas of the nose were treated at the M. D. Anderson Hospital during the years 1944-1978.

Results of treatment for squamous carcinoma of the lower gum.

The records of 61 patients with a diagnosis of squamous carcinoma of the lower alveolar ridge were reviewed. The overall two-year survival was 67% with a local or regional failure of 5%. The majority of patients were treated with surgery initially with an excellent local control of 98%, if the patient who died in the postoperative period and the patient lost to follow-up are excluded.

Prolatin secreting pituitary adenomas.

Prolactin secreting adenomas are the most frequently (50%) occurring pituitary adenoma. They occur more commonly in women than in men (4:1). Impairment of gonadal function accounts for the predominant symptoms in both sexes.

What is the preferred initial method of treatment for squamous carcinoma of the tongue?

The medical records of 152 previously untreated patients with squamous carcinoma of the tongue were reviewed. Radiation, surgery and the combination of both were analyzed with respect to the stage of disease treated, local and regional failure and ultimate salvage. The plan of treatment for a prospective patient is formulated based on the data.

Malignant melanoma of the external ear. Review of 102 cases.

The medical records of 102 patients with a diagnosis of melanoma of the external ear seen at The M.D. Anderson Hospital over approximately a 30 year period were reviewed.

Use of surgery and postoperative radiation in the treatment of advanced squamous cell carcinoma of the pyriform sinus.

Forty-seven patients with very advanced cancer of the pyriform sinus were treated with surgery and immediate postoperative radiation in a planned sequential manner. Eradication of the cancer above the clavicles was obtained in 81% of the patients, with a treatment mortality of 8%. Most of the patients' tumors were resected with primary closure, which obviated the need for complicated reconstructive procedures.