Synthesis and Anti-Inflammatory Activity of (2)-Arylindazol-3(2)-One Derivatives: Copper-Promoted Direct -Arylation via Chan-Evans-Lam Coupling.

Inflammatory-related diseases are becoming increasingly prevalent, leading to a growing focus on the development of anti-inflammatory agents, with a particular emphasis on creating novel structural compounds. In this study, we present a highly efficient synthetic method for direct -arylation to produce a variety of (2)-arylindazol-3(2)-ones , which exhibit anti-inflammatory activity. The Chan-Evans-Lam (CEL) coupling of (1)-benzyl-indazol-3-(2)-ones with arylboronic acids in the presence of a copper complex provided the corresponding (2)-arylindazol-3(2)-ones in good-to-excellent yields, as identified with NMR, MS, and X-ray crystallography techniques.

Stable carbamate pathway towards organic-inorganic hybrid perovskites and aromatic imines.

Methyl ammonium methyl carbamate (MAC), formulated as CHNH CHNHCO , was synthesized by reacting liquid methylamine with supercritical CO, and its structure was refined by single-crystal X-ray diffraction. MAC is a white crystalline salt and is as reactive as methylamine, and is a very efficient alternative to toxic methylamine. We were able to produce hybrid perovskite MAPbI (MA = methyl ammonium) by grinding MAC with PbI and I at room temperature, followed by storing the mixed powder.

Understanding CO capture mechanisms in aqueous hydrazine via combined NMR and first-principles studies.

Aqueous amines are currently the most promising solution for large-scale CO capture from industrial sources. However, molecular design and optimization of amine-based solvents have proceeded slowly due to a lack of understanding of the underlying reaction mechanisms. Unique and unexpected reaction mechanisms involved in CO absorption into aqueous hydrazine are identified using H, C, and N NMR spectroscopy combined with first-principles quantum-mechanical simulations.

Active digital microfluidic paper chips with inkjet-printed patterned electrodes.

Active, paper-based, microfluidic chips driven by electrowetting are fabricated and demonstrated for reagent transport and mixing. Instead of using the passive capillary force on the pulp to actuate a flow of a liquid, a group of digital drops are transported along programmed trajectories above the electrodes printed on low-cost paper, which should allow point-of-care production and diagnostic activities in the future.

Dual Pd and CuFe2O4 nanoparticles encapsulated in a core/shell silica microsphere for selective hydrogenation of arylacetylenes.

A dual catalyst containing Pd and CuFe(2)O(4) nanoparticles in a silica shell exhibits >98% conversion of arylacetylenes to related styrenes with selectivity greater than 98%, which are better than those obtained using a commercial Lindlar catalyst. The excellent synergy was likely a result of the proximal interaction between Pd and CuFe(2)O(4) nanoparticles.

Synthesis of azines in solid state: reactivity of solid hydrazine with aldehydes and ketones.

Highly conjugated azines were prepared by solid state grinding of solid hydrazine and carbonyl compounds such as aldehydes and ketones, using a mortar and a pestle. Complete conversion to the azine product is generally achieved at room temperature within 24 h, without using solvents or additives. The solid-state reactions afford azines as the sole products with greater than 97% yield, producing only water and carbon dioxide as waste.

Isolation and structural characterization of the elusive 1:1 adduct of hydrazine and carbon dioxide.

A solid hydrazine was isolated as a crystalline powder by reacting aqueous hydrazine with supercritical CO(2). Its structure determined by single crystal X-ray diffraction shows a zwitterionic form of NH(3)(+)NHCO(2)(-). The solid hydrazine is remarkably stable but is as reactive as liquid hydrazine even in the absence of solvents.