A Desmethylphosphinothricin Dipeptide Derivative Effectively Inhibits and Growth.

New antibiotics are unquestionably needed to fight the emergence and spread of multidrug-resistant bacteria. To date, antibiotics targeting bacterial central metabolism have been poorly investigated. By determining the minimal inhibitory concentration (MIC) of desmethylphosphinothricin (Glu-γ-P), an analogue of glutamate with a phosphinic moiety replacing the γ-carboxyl group, we previously showed its promising antibacterial activity on .

Antibacterial Activity of Peptide Derivatives of Phosphinothricin against Multidrug-Resistant .

The fast spread of bacteria that are resistant to many classes of antibiotics (multidrug resistant) is a global threat to human and animal health with a worrisome scenario ahead. Novel therapeutical strategies are of crucial importance to combat this phenomenon. For this purpose, we investigated the antimicrobial properties of the naturally occurring tripeptide Bialaphos and a dipeptide -leucyl--phosphinoithricin, the synthesis and diastereomers separation of which are herein described.

Antimicrobial Activity of Microorganisms Isolated from Ant Nests of .

In this study, the microbial communities of two nests of black garden ants ) in the hollows of stem branches of old apple trees were found to have similar species compositions: each community contained representatives of three species from the Bacillaceae family and one species of actinomycetes from the genus . In total, four types of bacilli and two actinomycetes were isolated. Actinomycetes were identified as -like and sp.