Publications by authors named "Buze Chen"
Background: The impact of microRNA-1301-3p (miR-1301-3p) on various cancer subtypes is noteworthy. However, its specific role within the framework of uterine corpus endometrial carcinoma (UCEC) is yet to be clearly defined.
Objective: The objective of this research was to investigate and clarify the function of miR-1301-3p in relation to UCEC.
Article Synopsis
- Cyclophilin A (CypA) is identified as a key driver of epithelial-mesenchymal transition (EMT) in ovarian cancer, correlating higher expression with poor patient prognosis.
- The study reveals that CypA promotes tumor growth and metastasis by activating the PI3K/AKT signaling pathway, while it also interacts with TAF15 to stabilize it, creating a feedback loop that enhances CypA's effects.
- This research outlines a novel pathway involving STAT5A, miR-514a-3p, and CypA, suggesting potential therapeutic opportunities and diagnostic applications for ovarian cancer treatment.
Background: The role of Zinc Finger Protein 695 (ZNF695) is unclear in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC).
Objective: The objective of this study was to conduct a comprehensive analysis and experimental validation of ZNF695 in CESC.
Methods: The study investigated the expression of ZNF695 in both pan-cancer and CESC, utilizing data from The Cancer Genome Atlas (TCGA) database to assess its diagnostic value.
Background: Aberrant expression of tumor protein D52 (TPD52) is associated with some tumors. The role of TPD52 in uterine corpus endometrial carcinoma (UCEC) remains uncertain.
Objective: We aimed to investigate the involvement of TPD52 in the pathogenesis of UCEC.
Background: Some tumors have a poor prognosis regarding TPD52 (tumor protein D52). This study aims to explore TPD52's role in the cancer process from a pan-cancer perspective.
Methods: A pan-cancer analysis was conducted to investigate how TPD52 may be involved in cancer as well as its association with prognosis.
Pathway Genes in Ovarian Cancer: Clinical Significance and Associations with Immune Cell Infiltration.
Front Biosci (Landmark Ed)
September 2023
Background: Activation of the signaling pathway is associated with tumorigenesis. The aim of this study was to investigate pathway gene functions and regulatory mechanisms in ovarian cancer (OC).
Methods: We conducted a bioinformatics analysis of publicly available datasets in order to identify potential -related mechanisms, associated genes, biological pathways, and their relation to immune function.
T cell leukemia homeobox 2 (TLX2) plays an important role in some tumors. Bioinformatics and experimental validation represent a useful way to explore the mechanisms and functions of TLX2 gene in the cancer disease process from a pan cancer perspective. TLX2 was aberrantly expressed in pan cancer and cell lines and correlated with clinical stage.
View Article and Find Full Text PDFThe long non-coding RNA (LncRNA) PAXIP1 antisense RNA 1 (PAXIP1-AS1) was found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis, and immune infiltration of OC patients and its regulatory network are unclear. 379 OC tissues were collected from The Cancer Genome Atlas (TCGA) database. 427 OC tissues and 88 normal ovarian tissues were collected from GTEx combined TCGA database.
View Article and Find Full Text PDFExperimental Research on a New Mini-Channel Transcritical CO Heat Pump Gas Cooler.
Micromachines (Basel)
May 2023
Article Synopsis
- The paper investigates a new spiral plate mini-channel gas cooler designed for supercritical CO, focusing on its heat transfer and pressure drop characteristics.
- Increasing the mass flux of CO and inlet water temperature improves the overall heat transfer coefficient, with vertical orientation yielding better results than horizontal.
- A Matlab program confirmed the accuracy of heat transfer correlations based on Zhang's method, providing valuable insights for future gas cooler designs.
Molecular Analysis of Prognosis and Immune Infiltration of Ovarian Cancer Based on Homeobox D Genes.
Comput Math Methods Med
October 2022
Background: Homeobox D (HOXD) genes were associated with cancer pathogenesis. However, the role of HOXD genes in ovarian cancer (OC) and the possible mechanisms involved are unclear. In this study, we analyzed the function and regulatory mechanisms and functions of HOXD genes in OC based on comprehensive bioinformatics analysis.
View Article and Find Full Text PDFBackground: Endocrine disruption is an important factor in the development of endometrial cancer. Expression of miR-149-3p is observed in some cancer types, while its role in uterine corpus endometrial carcinoma (UCEC) is unclear.
Methods: The clinical and genomic data and prognostic information on UCEC were obtained for patients from the TCGA database.
Ovarian cancer is one of the most common gynecological malignancies in women worldwide with a poor survival rate. Cinnamaldehyde (CA), a bioactive substance isolated from cinnamon bark, is a natural drug and has shown that it can inhibit the progression of other tumors. However, the role of CA in ovarian cancer and its mechanism is poorly understood.
View Article and Find Full Text PDFThe Immune-Related Gene ELF3 is a Novel Biomarker for the Prognosis of Ovarian Cancer.
Int J Gen Med
September 2021
Background: Ovarian cancer (OC) is a fatal gynaecological malignancy. The study aimed to conduct a comprehensive study to determine the role of ELF3 in OC through bioinformatic analysis.
Methods: Kruskal-Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical characteristics and ELF3 expression.
Background: The present study aims to explore the expression, clinical significance, and prospective pathway signaling of miR-501-3p in ovarian cancer (OC) based on database and informatics analysis.
Methods: Kruskal-Wallis test, Wilcoxon sign-rank test, and logistic regression were used to evaluate the relationship between clinical features and miR-501-3p expression. Kaplan-Meier survival curve analysis was used to explore the relationship between miR-501-3p expression and the prognosis of OC patients.
Background: The study aims to analyze the expression levels of kinesin family member 1A (KIF1A) in ovarian cancer (OC) and explore its clinical significance in the development of OC and its potential regulatory network.
Methods: The Cancer Genome Atlas (TCGA) OC data was used to examine the expression differences between OC and normal tissue and explore the correlation with tumor stage. The relationship between KIF1A expression and prognosis was analyzed using Oncomine and Kaplan-Meier plotter tools.
Background: Aberrant expression of microRNAs (miRNAs) contributes to the development of high grade serous ovarian cancer (HGSOC). However, the molecular mechanism by which miRNA-585-3p mediates high-grade serous ovarian carcinogenesis is unclear. This study aims to investigate the specific mechanism of action of miR-585-3p in HGSOC.
View Article and Find Full Text PDFBackground: The present study is aimed at providing systematic insight into the composition and expression of transfer RNA (tRNA) derivative transcription in high-grade serous ovarian cancer (HGSOC).
Methods: tRNA derivative expression profiles in three pairs of HGSOC and adjacent normal ovarian tissues were conducted by tRNA-derived small RNA fragment (tRF) and tRNA half (tiRNA) sequencing. The differentially expressed tRFs and tiRNAs between HGSOC and paired adjacent normal samples were screened.
Purpose: This research tried to explore the expression level of II cGMP-dependent protein kinase (PKG2) in human ovarian tissue and to clarify the molecular mechanism of EGFR regulation and its clinical significance.
Methods: The expression levels of PKG2 and EGFR in 10 normal ovarian tissues, 14 benign ovarian tumor tissues and 39 epithelial ovarian cancer tissues preserved in the archives of the Affiliated Hospital of Xuzhou Medical University from 2016 to 2018 were detected by real-time fluorescence quantitative (RT-PCR), and the correlation between the expressions of the two genes was analyzed. The expressions of in vitro cultured ovarian cancer cell lines SKOV3, PKG2 and EGFR were detected by RT-PCR and western blot, and the over-expressed PKG2 plasmid and PKG2 small interfering RNA (siRNA) were transfected into the cells, and the protein and phosphorylation of Akt and ERK in EGFR and its downstream signaling pathway were detected by western blot.