Publications by authors named "Buyun Song"
Background: The emergence of immune resistance and a lack of effective therapeutic targets have become significant challenges in immunotherapy, highlighting the urgent need for new molecular markers and treatment targets. Moreover, the significance and mechanisms of PGRN (Progranulin) in gastric cancer remain ambiguous.
Objective: To identify differentially expressed proteins in gastric cancer and elucidate the function and mechanism of PGRN.
Long noncoding RNAs (lncRNAs) serve as critical mediators of tumor progression and drug resistance in cancer. Herein, we identified a lncRNA, LINC00665, associated with trastuzumab resistance and development in gastric cancer (GC). LINC00665 was highly expressed in GC tissues and high expression of LINC00665 was correlated with poor prognosis.
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- Scientists found that a special type of small circular RNA called circ_0001947, which comes from gastric cancer cells, can make cancer worse and reduce the body’s immune response against the cancer.
- They used different experiments to see how this circRNA affects cancer cells and immune cells, discovering that it helps cancer cells grow and move around by affecting other molecules in the body.
- The study suggests that targeting this circRNA might help improve treatments for gastric cancer by boosting the immune system's ability to fight the cancer.
Gastric cancer (GC) is difficult to characterize due to its heterogeneity, and the complicated heterogeneity leads to the difficulty of precisely targeted therapy. The spatially heterogeneous composition plays a crucial role in GC onset, progression, treatment efficacy, and drug resistance. In recent years, the technological advancements in spatial omics has shifted our understanding of the tumor microenvironment (TME) from cancer-centered model to a dynamic and variant whole.
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