Purpose: [Lu]Lu-DOTATATE and [Lu]Lu-PSMA-617 used for targeted radionuclide therapy are very often prepared in the hospital radiopharmacy. The preparation parameters vary depending upon the specific activity of the Lu used. The aim of this study was to develop optimized protocols to be used in the nuclear medicine department for the preparation of patient doses of the above radiopharmaceuticals.
View Article and Find Full Text PDFPurpose: The clinical demand of 6l F] FDOPA is gaining rapidly for imaging neurodegenerative diseases by using positron emission tomography. Hence, large-scale production of 6-l-[F] FDOPA is necessary. This paper describes our experience on the production of 6-l-[F]FDOPA via nucleophilic synthesis using NEPTIS module and a commercially available cassette based chemistry.
View Article and Find Full Text PDFReprocessed high-level nuclear waste (HLW) contains range of radioactive components. Crystalline oxyphosphate apatite ceramic of the formula LaSr(PO)O [LSS] was investigated as a host for HLW immobilisation. The systematic study of solid solubility limit of individual rare earth ion substitution leads to the formulation of simulated wasteform of the formula LaPrNdSmGdSr(PO)O (WF1) with the waste loading of 17.
View Article and Find Full Text PDFThe present study reports on CuO-assisted reduction of Cr(VI) under ambient conditions using sodium borohydride and its complete removal. The confirmation of the reductive removal of Cr(VI) was assisted by powder X-ray diffraction, Fourier transform infrared, scanning electron microscopy, mic absorption spectro, UV-vis, and UV-vis-diffuse reflectance spectroscopy techniques. The analysis revealed that the process involved adsorption of dichromate ion on the surface of copper oxide, reduction of Cr(VI), and precipitation of Cr(III) as its hydroxide.
View Article and Find Full Text PDFThe oxysilicate apatite host CaLa(SiO)O has been explored for immobilization of radioactive nuclides. Divalent ion, trivalent rare earth ion, and combined ionic substitutions in the silicate oxyapatite were carried out to optimize the simulated wasteform composition. The phases were characterized by powder X-ray diffraction, FT-IR, TGA, SEM-EDS, and HT-XRD techniques.
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