Effectiveness of Subcutaneous Casirivimab and Imdevimab in Ambulatory Patients with COVID-19.

Introduction: Data on real-world effectiveness of subcutaneous (SC) casirivimab and imdevimab (CAS+IMD) for the treatment of coronavirus disease 2019 (COVID-19) are limited. The objective of this study was to assess the effectiveness of SC CAS+IMD versus no antibody treatment among patients with COVID-19.

Methods: This retrospective cohort study linked Komodo Health and CDR Maguire Health and Medical data.

Diversity and Dynamics of the Canadian Coastal Vibrio Community: an Emerging Trend Detected in the Temperate Regions.

species are indigenous to the marine and estuarine environments around the world and are the leading cause of water- and seafood-borne illnesses due to conditions favoring the transmission and growth of the species. Horizontal gene transfer, recombination, and mutation enable spp. to adapt rapidly to environmental challenges from biotic and abiotic parameters, including temperature, salinity, and nutrient status of the coastal waters.

Outbreak of type E foodborne botulism linked to traditionally prepared salted fish in Ontario, Canada.

On April 17, 2012, two adult females presented to the hospital with symptoms of botulism. Patient A displayed shortness of breath, increasing lethargy, ptosis, and fixed and dilated pupils, and was intubated after admission. Patient B presented with shortness of breath, vomiting, and stridor.

An integrated approach to gene discovery and marker development in Atlantic cod (Gadus morhua).

Atlantic cod is a species that has been overexploited by the capture fishery. Programs to domesticate this species are underway in several countries, including Canada, to provide an alternative route for production. Selective breeding programs have been successfully applied in the domestication of other species, with genomics-based approaches used to augment conventional methods of animal production in recent years.

In situ reductive dechlorination of chlorinated ethenes in high nitrate groundwater.

In situ bioremediation using carbohydrate was evaluated as an in situ treatment alternative for trichloroethene (TCE) and cis-1,2-dichloroethene (cDCE) in groundwater containing high nitrate concentrations. Upon addition of carbohydrate to groundwater, sequential reduction of electron acceptors was observed, where nitrate was reduced early in the pilot test, followed by sulfate and TCE. Reduction of cDCE to vinyl chloride and ethene occurred in conjunction with increased iron and manganese, and increased methane concentrations, approximately 7 months into the evaluation period, following depletion of nitrate and sulfate.

Evaluation of the BAX gel and fluorometric systems for the detection of foodborne Salmonella.

The present study compared the sensitivity of the BAX automated fluorometric and the recently discontinued BAX gel electrophoresis systems with a standard culture method to detect Salmonella in 333 high-moisture and 171 low-moisture foods. A total of 95 naturally contaminated foods, including 63 high-moisture and 32 low-moisture foods, were detected by the standard culture method. No contaminated samples were identified exclusively by the BAX systems.

Retrotransposons and tandem repeat sequences in the nuclear genomes of cryptomonad algae.

The cryptomonads are an enigmatic group of unicellular eukaryotic algae that possess two nuclear genomes, having acquired photosynthesis by the uptake and retention of a eukaryotic algal endosymbiont. The endosymbiont nuclear genome, or nucleomorph, of the cryptomonad Guillardia theta has been completely sequenced: at only 551 kilobases (kb) and with a gene density of approximately 1 gene/kb, it is a model of compaction. In contrast, very little is known about the structure and composition of the cryptomonad host nuclear genome.

Detection of Cyclospora cayetanensis oocysts in human fecal specimens by flow cytometry.

A diagnosis of cyclosporiasis typically involves stool examinations for the presence of Cyclospora oocysts by means of microscopy. In recent years, flow cytometry has been gaining in popularity as a novel method of detecting pathogens in environmental and clinical samples. The present study is an evaluation of a flow cytometric method for the detection and enumeration of Cyclospora oocysts in human fecal specimens associated with food-borne outbreaks of cyclosporiasis in Ontario, Canada.

Pediatric splenic injuries with a contrast blush: successful nonoperative management without angiography and embolization.

Background: The presence of a contrast blush on computed tomography (CT) in adult splenic trauma is a risk factor for failure of nonoperative management. Arterial embolization is believed to reduce this failure rate. The significance of a blush in pediatric trauma is unknown.

Open and laparoscopic appendectomy are equally safe and acceptable in children.

Background: The aim of this study was to evaluate prospectively whether laparoscopic (LA) and open appendectomy (OA) are equally safe and feasible in the treatment of pediatric appendicitis.

Methods: A total of 517 children with acute appendicitis were randomly assigned to undergo LA or OA appendectomy, based on the schedule of the attending surgeon on call. Patient age, sex, postoperative diagnosis, operating time, level of training of surgical resident, length of postoperative hospitalization, and minor and major postoperative complications were recorded.

Minimal-access fetal surgery for twin-to-twin transfusion syndrome.

Background: Laser ablation of placental vessels effectively halts severe twin-to-twin transfusion syndrome (TTTS), but fetal surgery remains a dangerous approach. The authors present the technical aspects of endoscopic fetal surgery in their initial clinical experience.

Methods: Altogether, 11 women underwent endoscopic fetal surgery for severe TTTS.

Small bowel obstruction in an adolescent with pelvic inflammatory disease due to Chlamydia trachomatis.

A 19-yr-old adolescent, who was hospitalized because of pelvic inflammatory disease (PID) due to Chlamydia trachomatis, developed bile-stained emesis. A mild amount of free fluid in the pelvis was found on abdominal ultrasound but there was no sonographic evidence of a pelvic mass or of a tubo-ovarian abscess. Plain radiography and computer tomography (with contrast) of the abdomen revealed a high-grade partial small bowel obstruction.

Why a large tip electrode makes a deeper radiofrequency lesion: effects of increase in electrode cooling and electrode-tissue interface area.

Introduction: Increasing electrode size allows an increase in radiofrequency lesion depth. The purpose of this study was to examine the roles of added electrode cooling and electrode-tissue interface area in producing deeper lesions.

Methods And Results: In 10 dogs, the thigh muscle was exposed and superfused with heparinized blood.

The psychosocial issues of women serving time in jail.

Two hundred and one randomly selected female inmates incarcerated at a municipal jail were interviewed to establish the needs of this population and to formulate appropriate rehabilitative interventions. Measures of social support for this sample were uniformly low. Scores on the Global Severity Index of the Brief Symptom Inventory showed that 64 percent of the women were in the clinical range for mental health problems.