Publications by authors named "Busra Kandilli"
Article Synopsis
- This study focused on creating and testing orally disintegrating tablets (ODTs) that combine levetiracetam (LEV) and carbamazepine (CBZ) for epilepsy treatment using two preparation methods: lyophilization and direct compression.
- The direct compression method showed suitable flow properties for powder blending, with quality control tests indicating both formulations had desirable characteristics like fast disintegration and low friability.
- The combination of CBZ and LEV in the ODTs resulted in more effective seizure reduction in a rat model compared to treatment with either drug alone, suggesting that this formulation could enhance epilepsy management.
The aim of this study was to develop the PLGA nanoparticles (NPs) containing carbamazepine (CBZ) and levetiracetam (LEV) combination (CBZ + LEV) for the treatment of epilepsy and to characterize the prepared NPs. LEV and CBZ, which are antiepileptic drugs, are used in the treatment of epilepsy. Nano-sized formulations are prepared to use for different purposes such as to improve the solubility/the physicochemical properties and bioavailability of drugs, to decrease their doses and frequency of administration, and to reduce side effects of drugs.
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