Paroxetine: An update of response on intestinal motility.

Objective: To find out the possible effects of paroxetine on gastrointestinal smooth muscles in vitro as they can cause severe nausea and vomiting at the start of therapy which later settles down.

Methods: Power lab (USA) was used for recording the contractions of ileal smooth muscle of rabbits in response to acetylcholine, serotonin and paroxetine.

Results: The percent responses with acetylcholine, serotonin and paroxetine were 100, 158.