Publications by authors named "Bushi G"
Association Between SHBG Levels and Hypertensive Disorders of Pregnancy: A Systematic Review and Meta-Analysis.
J Clin Hypertens (Greenwich)
January 2025
Sex hormone-binding globulin (SHBG) regulates sex hormone availability and is influenced by metabolic factors. Variations in SHBG levels during pregnancy may affect the development of hypertensive disorders such as gestational hypertension (GH) and preeclampsia (PE). This systematic review and meta-analysis explores the potential of SHBG as a biomarker for predicting GH and PE.
View Article and Find Full Text PDFObjective: Asthma poses a significant health burden in South Asia, with increasing incidence and mortality despite a global decline in age-standardized prevalence rates. This study aims to analyze asthma trends from 1990 to 2021, focusing on prevalence, incidence, mortality, and disability-adjusted life years (DALYs) across South Asia. The study also assesses the impact of risk factors like high body mass index (BMI), smoking, and occupational exposures on asthma outcomes.
View Article and Find Full Text PDFBackground: Diabetes mellitus presents significant public health challenges worldwide. While its prevalence and management in the general population have been extensively studied, comprehensive research on diabetes among incarcerated individuals is lacking. This study aims to conduct a systematic review and -analysis to determine the prevalence of diabetes within the prison population.
View Article and Find Full Text PDFBackground: Sex hormone-binding globulin (SHBG) plays a critical role in regulating androgen bioavailability and has been hypothesized to influence prostate cancer risk, though existing evidence is inconsistent. This systematic review and meta-analysis aimed to evaluate the association between SHBG levels and prostate cancer risk.
Methods: A comprehensive search was conducted across PubMed, Embase, and Web of Science for studies published up to December 1, 2024.
Background: The rapid rise of non-communicable diseases, particularly type 2 diabetes mellitus (T2DM), poses a significant global public health challenge, with South Asia experiencing an increasingly severe burden. This study aimed to analyse historical trends of T2DM across South Asia from 1990 to 2021 and forecast incidence through 2031.
Research Design And Methods: We carried out analysis based on the data from the 2021 Global burden of disease study.
Background: Atrial fibrillation (AF) is the most prevalent form of sustained cardiac arrhythmia, with vascular endothelial growth factor (VEGF) increasingly recognized for its potential role in the pathogenesis of AF through mechanisms involving atrial remodeling, inflammation, and fibrosis. This systematic review aims to synthesize available evidence on the association between VEGF and AF, exploring the implications of VEGF as a biomarker and therapeutic target.
Methods: We conducted a comprehensive search across PubMed, Embase, and Web of Science until November 10 2024, selecting studies based on pre-defined criteria that involve adults with AF and measurements of VEGF levels.
Hypoalbuminemia as a predictor of severe dengue: a systematic review and meta-analysis.
Expert Rev Anti Infect Ther
January 2025
Article Synopsis
- Dengue fever is a major health issue globally, particularly in tropical regions, where identifying hypoalbuminemia helps in diagnosing severe cases early.
- A systematic review of 17 studies found a significant difference in albumin levels between severe and non-severe dengue patients, with higher hypoalbuminemia noted in children.
- The research confirms that low albumin levels are a key predictor of severe dengue, which can help healthcare providers improve patient care through tailored treatment plans.
Background: Pneumococcal disease, caused by Streptococcus pneumoniae, imposes a significant global health burden, particularly affecting vulnerable groups such as the elderly and immunocompromised. The 23-valent pneumococcal polysaccharide vaccine (PPV23) is designed to protect against 23 serotypes of Streptococcus pneumoniae. However, there is ongoing debate about its effectiveness in reducing all-cause mortality.
View Article and Find Full Text PDFMpox, formerly known as monkeypox, has re-emerged as a significant global health concern, particularly during the widespread outbreak of 2022. As an orthopoxvirus related to the eradicated smallpox virus, mpox has been primarily managed with smallpox vaccines and treatments, including the antiviral agent Tecovirimat. This systematic review aims to evaluate the effectiveness and safety of Tecovirimat in treating mpox, focusing on its use during the 2022 outbreak, especially among high-risk populations, including men who have sex with men and people living with HIV.
View Article and Find Full Text PDFBackground: Neurological disorders are a major global health concern, especially in BRICS nations (Brazil, Russia, India, China, South Africa), where demographic and socio-economic changes have amplified their impact. This study evaluates trends in incidence, prevalence, mortality, and Disability-Adjusted Life Years (DALYs) associated with neurological diseases in these countries from 1990 to 2021, focusing on sex disparities and key risk factors.
Methods: Data were obtained from the Global Burden of Disease (GBD) 2021 database.
Objectives: The objectives of this study were to analyze trends in prostate cancer incidence, incidence, mortality, and disability-adjusted life years (DALYs) from 1990 to 2021 via data from the Global Burden of Disease (GBD) study in South Asia. Additionally, the study projects future prostate cancer incidence rates up to 2031 to inform public health interventions in South Asia.
Methods: Data covering South Asian countries such as Bangladesh, Bhutan, India, Nepal, and Pakistan were obtained from the GBD 2021 portal.
Kumbh Mela 2025: A perfect storm for Zika, Nipah, and Mpox in India?
New Microbes New Infect
December 2024
Article Synopsis
- The outbreak of Monkeypox (Mpox), especially the clade 1b variant, has become a significant global health issue, particularly in Africa, which is experiencing ongoing epidemics that require urgent attention and study.
- This research analyzes data from the most affected African countries, using time series techniques to predict Mpox trends and assess the growth in new cases from August 2023 to August 2024.
- Results indicate a worrying upward trend in Mpox cases, with projections suggesting nearly 6,923 cumulative cases in about 65 weeks, highlighting the need for ongoing monitoring and tailored public health responses to manage the outbreak effectively.
Article Synopsis
- West Nile Virus (WNV) poses a significant global health risk, expanding into new regions due to climate change enhancing mosquito activity, leading to year-round virus transmission.
- Recent advancements in genomic technologies have improved understanding of WNV's behavior and potential treatment options, yet the lack of an approved vaccine means management relies heavily on supportive care for severe cases.
- There is a pressing need for innovative vector control methods and adaptive public health strategies that integrate research, policy, and community efforts to effectively combat WNV's evolving challenges.
Reversible cerebral vasoconstriction syndrome (RCVS) is a rare neurological disorder characterized by transient constriction and dilation of cerebral arteries, leading to severe headaches and neurological deficits. This case report describes a 41-year-old woman with chronic anemia, acute chronic kidney disease, type 2 diabetes mellitus, and rheumatoid arthritis who developed RCVS following transfusion of packed red blood cells (PRBCs). She experienced sudden-onset seizures and a thunderclap headache 5 days post-transfusion.
View Article and Find Full Text PDFArticle Synopsis
- People living with HIV (PLWH) face increased mortality risks from air pollution due to chronic inflammation and immune dysfunction, a link that has not been widely studied.
- A systematic review analyzed nine studies, primarily from China, revealing that long-term exposure to pollutants like particulate matter significantly correlates with higher AIDS-related and overall mortality rates in PLWH, with certain populations being more susceptible.
- The findings indicate that targeted interventions to lessen air pollution exposure could benefit vulnerable groups, emphasizing the need for further research in this area.
Article Synopsis
- The COVID-19 pandemic has had serious effects on maternal and neonatal health, prompting a systematic review to assess how it influences respiratory distress syndrome (RDS) in newborns from infected mothers.
- The review analyzed 22 studies and found that 11.5% of newborns from COVID-19-positive mothers experienced RDS, with a risk ratio of 2.69 indicating a significantly higher risk compared to newborns from non-infected mothers.
- The findings stress the importance of closely monitoring and managing pregnant women with COVID-19 to reduce potential health issues in their newborns.
Article Synopsis
- E-cigarettes are becoming popular as a way for people to quit smoking, but there are concerns about their use alongside traditional cigarettes, particularly among pregnant women, who may face increased health risks.
- A systematic review analyzed data from 18 studies involving nearly 6 million pregnant women, finding that 4.6% of them reported using both e-cigarettes and traditional tobacco.
- The findings suggest that dual use is a significant health issue, highlighting the need for further research and public health measures to inform and protect pregnant women from the risks of tobacco.
Article Synopsis
- Celiac disease (CD) is an autoimmune disorder linked to gluten intolerance that may affect cardiovascular health, with some studies suggesting a connection to myocardial infarction (MI), although results have been inconsistent.* -
- A systematic review and meta-analysis of 8 studies were conducted to evaluate the risk of MI in adults with CD, using data from databases like PubMed and Web of Science, analyzed with R software.* -
- The analysis found no significant association between CD and MI, but indicated high variability in study results, suggesting a need for more research on larger, more uniform samples to clarify potential cardiovascular risks for CD patients.*