Essential Oil and Supercritical Carbon Dioxide Extract of Grapefruit Peels Formulated for Infections: Evaluation by an Model to Study Fungal-Host Interactions.

Resistance to currently available antifungal agents raises the need to develop alternative remedies. is the most common opportunistic pathogenic fungus of humans, colonizing in the genital and intestinal mucosa, skin, and oral-nasal cavity and reducing quality of life. Herein, essential oil from grapefruit () peels was obtained by hydrodistillation, and the remaining plant material was sequentially subjected to supercritical carbon dioxide (SC-CO) extraction to determine the conditions for maximizing phenolic compounds.