Comparison of three different molecular biology assays (AllPlexH. pylori & ClariR assay, Amplidiag® H. pylori + ClariR and RIDA®GENE Helicobacter pylori) to detect Helicobacter pylori and clarithromycin resistance in stool samples.

Helicobacter pylori detection and susceptibility profile using feces could optimize guided therapy, when endoscopy is not necessary. This study evaluated the performances of three tests: AllPlexH.pylori&ClariR, RIDAGENEHelicobacterpylori and AmplidiagH.

Lethal Case of Microbacterium paraoxydans Bloodstream Infection Associated with Mitral Endocarditis in Human: A Case Report, analyses of the 16S rDNA sequences and review of the literature.

Introduction: Microbacterium species are gram-positive, non-fermentative, yellow-pigmented rods commonly found in animals and various environmental sources. Herein is reported the first case of a fatal bloodstream infection associated with mitral endocarditis caused by Microbacterium paraoxydans in a human patient.

Methods: A 64-year-old man without significant infectious risk factors, except for rheumatoid spondylarthritis treatment, developed severe chest pain, paralysis of the left leg, respiratory distress, and high fever.

Diagnostic performance of the DISQVER metagenomic sequencing tool for the identification of pathogens in febrile neutropenic patients: the ADNEMIA trial.

Introduction: While intensive protocols in onco-haematology have improved survival rates for patients with haematological malignancies, they have also resulted in an increased incidence of infection associated with therapy-induced immunosuppression (including chemotherapy-induced febrile neutropenia; FN). The occurrence of FN, associated with high morbidity and mortality, necessitates broad-spectrum antibiotic therapy, occasioning delayed chemotherapy and resulting in a loss of opportunity for the patient. Considering that without an identified pathogen, a 10% mortality rate can ensue, documentation is essential to the optimisation of antibiotic therapy.

Low-level primary clarithromycin resistance of Helicobacter pylori in Reunion Island.

Introduction: The increasing resistance of Helicobacter pylori to clarithromycin leads to an ongoing adaptation of empirical first-line treatment for H. pylori infections.

Patients And Methods: Prospective study (2022-2023) of 364 patients with no previous treatment for H.

Prioritisation of infectious diseases from a public health perspective: a multi-criteria decision analysis study, France, 2024.

BackgroundWithin the International Health Regulations framework, the French High Council for Public Health was mandated in 2022 by health authorities to establish a list of priority infectious diseases for public health, surveillance and research in mainland and overseas France.AimOur objective was to establish this list.MethodsA multi-criteria decision analysis was used, as recommended by the European Centre for Disease Prevention and Control.

In vitro activity of delafloxacin against clinical levofloxacin-resistant Helicobacter pylori isolates.

Background: Increasing antibiotic resistance in Helicobacter pylori necessitates research on new active molecules. In 2017, delafloxacin, a new fluoroquinolone with chemical properties of activity under acidic conditions, was approved for treatment of community-acquired bacterial pneumonia and acute bacterial skin and soft-tissue infections. Mutations in gyrA are responsible for fluoroquinolone resistance, but certain clinical isolates of H.

In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori.

Background: The main antibiotics used against Helicobacter pylori have been chosen empirically over time, with few preclinical studies to provide support. The rise in resistance to some of these antibiotics is prompting a reassessment of their use. This work aimed to evaluate the in vitro efficacy of 2 × 2 combinations of the most widely used antibiotics against H.

Bacteremia due to Lachnoanaerobaculum umeaense in a patient with acute myeloid leukemia during chemotherapy: A case report, and a review of the literature.

The present case reports a bacteremia due to Lachnoanaerobaculum umeaense (a Gram-positive, filamentous, rod-shaped, anaerobic, spore-forming bacillus present in the human oral microbiota) in a patient treated for acute myeloid leukemia. After failed identification by MALDI-TOF, identification was done by sequencing of 16s rRNA. The patient was successfully treated with Amoxicillin-clavulanic acid and ciprofloxacin for seven days.

The First Lethal Infection by : A Case Report and Review of the Literature.

is a Gram-negative bacillus, a member of the family, that had never previously been reported as lethal. Herein, a case of fatal infection caused by in an elderly woman with suspected bladder cancer is reported. The species identification was confirmed through Sanger sequencing of the bacterial 16S rRNA sequence and compared to published sequences for phylogenetic analysis.

Mice prenatally exposed to valproic acid do not show autism-related disorders when fed with polyunsaturated fatty acid-enriched diets.

Dietary supplementations with n-3 polyunsaturated fatty acid (PUFA) have been explored in autism spectrum disorder (ASD) but their efficiency and potential in ameliorating cardinal symptoms of the disease remain elusive. Here, we compared a n-3 long-chain (LC) PUFA dietary supplementation (n-3 supp) obtained from fatty fish with a n-3 PUFA precursor diet (n-3 bal) obtained from plant oils in the valproic acid (VPA, 450 mg/kg at E12.5) ASD mouse model starting from embryonic life, throughout lactation and until adulthood.

French national epidemiology of bacterial superinfections in ventilator-associated pneumonia in patients infected with COVID-19: the COVAP study.

Background: Description and comparison of bacterial characteristics of ventilator-associated pneumonia (VAP) between critically ill intensive care unit (ICU) patients with COVID-19-positive, COVID + ; and non-COVID-19, COVID-.

Methods: Retrospective, observational, multicenter study that focused on French patients during the first wave of the pandemic (March-April 2020).

Results: 935 patients with identification of at least one bacteriologically proven VAP were included (including 802 COVID +).

Diagnostic and Therapeutic Management of Infection in Primary Care: Perspective of Application in France and Narrative Review of the Literature.

Background: () infection affects 30% to 40% of people in industrialized countries.

Aim: This study aimed to synthesize knowledge on the diagnostic and therapeutic management of infection in general practice in people under 40 years of age.

Method: A narrative review of the literature with an inductive content analysis of the articles was performed.

IL-17 and IL-22 are pivotal cytokines to delay wound healing of infected skin.

Introduction: Although the presence of pathogens in skin wounds is known to delay the wound healing process, the mechanisms underlying this delay remain poorly understood. In the present study, we have investigated the regulatory role of proinflammatory cytokines on the healing kinetics of infected wounds.

Methods: We have developed a mouse model of cutaneous wound healing, with or without wound inoculation with and , two major pathogens involved in cutaneous wound bacterial infections.

Impact of Skin Disinfection on Cutaneous Microbiota, before and after Peripheral Venous Catheter Insertion.

Introduction. Patients with invasive medical devices are at high risk for infection. Skin colonization is the initial stage of these infections, leading to the recommendation of practices requiring disinfection using antiseptics.

How Did We End Up Using a Quadruple Guided Therapy Combining At Least Two Antibiotics with a PPI to Eradicate ?

Since the discovery of , and even if the species is frequently susceptible to many antibiotics , only six of them (amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and rifabutin) and bismuth salts could be considered as effective to eliminate and have been used in recommended eradication treatments [...

Guided Treatment of Infections with Non-Invasive PCR Tests-The Glory Days of Primary Care?

In the original article [...

Mutations Associated to Antibiotic-Resistant : It Is Time to Validate Sequencing Observations.

, a Gram-negative microaerophilic microorganism, is the only bacterial pathogen classified as a Class I carcinogen [...

Efficacy of Three Povidone Iodine Formulations against Assessed through In Vitro Studies: A Preliminary Study.

(, formerly known as ) is the major causative agent of prosthetic joint infections (PJI). Treatment of PJI with antibiotics is difficult due to antibiotic resistance and adverse side effects on patients' health. Proper disinfection of the surgical site using a variety of povidone iodine formulations could prevent infection.

Spermatic Microbiome Characteristics in Infertile Patients: Impact on Sperm Count, Mobility, and Morphology.

Through sperm alteration, semen microbiota tend to be recognized as a cause of infertility, but due to the limited number of studies focusing on this ecological niche, this hypothesis remains controversial. This study aimed to characterize and compare the bacterial communities of sperm samples from patients undergoing couple infertility treatment at the time of diagnosis. The study was prospective (September 2019 to March 2020), monocentric, and focused on alterations of spermatic parameters: count, motility, and morphology.

New Strategy for the Detection and Treatment of Infections in Primary Care Guided by a Non-Invasive PCR in Stool: Protocol of the French HepyPrim Study.

(Hp) infects half of the world population and is responsible for gastric, duodenal ulcers and gastric cancer. The eradication of Hp cures ulcers and prevents ulcer recurrences and gastric cancer. Antibiotic resistance of Hp, and particularly clarithromycin resistance, is the primary cause of treatment failure and is a major concern identified by the WHO as a high priority requiring research into new strategies.

Ulceroglandular Infection and Bacteremia Caused by Francisella salimarina in Immunocompromised Patient, France.

Although Francisella tularensis is a well-known, highly virulent bacterium that causes tularemia in humans, other Francisella species have been associated with sporadic human infections. We describe a human cutaneous infection with bacteremia caused by F. salimarina, a Francisella species recently identified from seawater and fishes, in an immunocompromised patient in France.

Listeria monocytogenes faecal carriage is common and depends on the gut microbiota.

Listeria genus comprises two pathogenic species, L. monocytogenes (Lm) and L. ivanovii, and non-pathogenic species.

K1 Antigen Is Associated with Different AST Profile in : A One-Month-Long Pilot Study.

is responsible for diseases of varying severity. The "K" antigen designates the capsular polysaccharides on the bacterial surface, which are mostly similar to those of highly pathogenic bacteria. The K1 antigen is often found in pathogenic .

Infection in Tripoli, North Lebanon: Assessment and Risk Factors.

() infection occurs among half of the general population worldwide, with high geographic variability. Even though is the leading cause of several gastric diseases, ranging from gastritis and peptic ulcers to gastric malignancies, such as gastric cancer and mucosa-associated lymphoid tissue lymphoma, most of the infections remain asymptomatic. Early detection and eradication of can definitely prevent severe long-term gastric diseases associated with .