Interleukin-1 upregulates anaphylatoxin receptors on mononuclear cells.

Background: The anaphylatoxins, C3a and C5a, that are generated during trauma, major surgery, or infection are potent proinflammatory mediators that increase interleukin (IL-1) cytokine synthesis. We investigated the effects of IL-1 on anaphylatoxin receptor expression in monocytes.

Methods: A human monocytic cell line, MONO-MAC-6, was used.