N6-methyladenosine-mediated overexpression of TREM-1 is associated with periodontal disease.

Periodontitis, a prevalent inflammatory disease, involves the destruction of tooth-supporting tissues. N6-methyladenosine (m6A) is a type of post-transcriptional modification that significantly influences gene and protein expression. It is involved in the regulation of various diseases, including those with an inflammatory component.

Overexpression of insulin-like growth factor-2 mRNA-binding protein 1 is associated with periodontal disease.

Objective: To investigate the potential role of a novel m6A RNA regulator, Insulin-like Growth Factor-2 mRNA-binding protein 1 (IGF2BP1), in periodontal disease pathogenesis.

Materials And Methods: Gingival tissue samples from 60 periodontitis patients and 60 healthy individuals were analyzed for IGF2BP1 mRNA and protein expression real-time quantitative PCR (RT-qPCR) and Western blotting. Additionally, Lipopolysaccharide (Pg-LPS) -induced human gingival fibroblasts (HGFs) were evaluated for IGF2BP1 and proinflammatory cytokine expression.

Anti-microbial activity of gel against black pigmented microbes.

Black pigmented gram negative anaerobes are associated with periodontal disease and tooth loss. Therefore, it is of interest to evaluate the antimicrobial activity of (Tulsi) gel against black pigmented anaerobes. Plaque samples were collected from the subject and kept in anaerobic broth for 4 hours of incubation at 37°C.

Effect of as LDD in periodontal therapy.

(Tulsi) has various properties like antibacterial, anti-inflammatory and anti-oxidant. To compare the effect of the local-drug delivery system containing 2% (Tulsi) as an adjunct to scaling and root planing (SRP).The main aim of the study was to evaluate the efficacy of (Tulsi) gel with Tetracycline fibers (Actisite) for the treatment of periodontitis patients.