Uncertainty Quantification and Flagging of Unreliable Predictions in Predicting Mass Spectrometry-Related Properties of Small Molecules Using Machine Learning.

Mass spectral identification (in particular, in metabolomics) can be refined by comparing the observed and predicted properties of molecules, such as chromatographic retention. Significant advancements have been made in predicting these values using machine learning and deep learning. Usually, model predictions do not contain any indication of the possible error (uncertainty) or only one criterion is used for this purpose.

[The method of calculation of maximally admissable mass of adipose-cutaneous flap, excised during abdominoplasty].

The dependence of a hypercoagulation state occurrence from value of the adipose-cutaneous flap mass, excised while performing abdominoplasty, was established, using the logistic regression method, in patients, suffering the anterior abdominal wall cosmetic defects and obesity. The possibility the hypercoagulation state occurrence raises nonlinearly together with such of the excised flap mass (% EFM), it exceeds 50% (high risk of hypercoagulation occurrence), when the EFM value constitutes 5.1% of the body mass.

[Antiatherogenic effect of abdominoplasty in patients with anterior abdominal wall deformity and obesity].

The impact on a lipids metabolism of a certain volume of fat tissue extraction from organism was investigated. With that objective there was determined the lipids content in a blood serum before and on a 14th day after abdominoplasty. In 73 patients (the main group) surgical interventions were performed on the organs of abdominal cavity, small pelvis and anterior abdominal wall with a simultant abdominoplasty, in 59 patients (a comparison group) abdominoplasty was not performed.

[Functional-anatomical prerequisites of revascularization of the femoro-popliteal arterial segment].

Improved results of surgical treatment of patients with critical ischemia of lower extremities can be obtained by using the collateral bed. The condition of the profound femoral artery and the popliteal artery, especially in the zone of its trifurcation, is of the greatest significance for the decision on the volume of surgery. The carrying capacity of the collateral bed of the profound femoral artery in occlusion of the femoral artery was on average 284 ml/min.

[Local tissue hypoxia consequence in the trophic venous ulceration in elderly patients].

This paper analyzes the data of examination and the results of the treatment of 25 patients aged over 80 years (mean age 68.5+/-7 years) suffering from varicosity with long nonhealing trophic ulcers of the distal limb segments (CVI CMP C6) and 20 patients of the same age groups with CVI CEAP stages 3-5. All patients with CVI underwent either full-scope phlebectomy (64.

Evaluation of microcirculation in elderly patients with venous trophic ulcers.

Altogether 112 patients over 50 years of age suffering from varicosity and chronic trophic ulcers of the distal limb segments were examined. The work was based on an analysis of the microcirculatory flow in lower limb tissues (laser Doppler flowmetry, BLF 21 system, Transonic Systems Inc., USA) and on the evaluation of tissue metabolism by measuring partial oxygen and carbon dioxide tension (percutaneous polarography; TCM-3 system, Radiometry Company, Denmark).

[Hemorheological disorders in patients with critical ischemia of the lower limbs of atherosclerotic genesis].

A comparative analysis of hemorheological indices was carried out in 105 patients with different variants of the course of critical ischemia of extremities and in 35 patients with intermittent claudication (as a reference group). Disturbances of the rheological properties of blood were revealed in the extremity muscles and in 62.4-68.

[Surgical treatment of patients with critical ischemia of the lower limbs of atherosclerotic etiology].

The authors analyze the results of conservative and operative treatment of 546 patients. The results of operative treatment (reconstructive operations on the arteries, osteo-trepanation) were shown to be considerably better in cases of critical ischemia than those of conservative treatment (infusion therapy, hemodilution, plasmapheresis).

[Evaluation of functional potentials of microcirculation in patients with obliterating diseases of lower limb vessels].

An analysis of the data of laser doppler fluorometry in 136 patients has shown that different obliterating diseases have different typical fluorometric features of changes in microcirculation. Results of the postischemic test are of greater informative value in the noninvasive assessment of the functional state of microcirculation. The significance of the functional tests was particularly increasing in critical ischemia of the lower extremities.