Targeting the lateral neck of superior articular process and sub-mammillary fossa for lumbar medial branch radiofrequency ablation: A case series.

Introduction: Lumbar medial branch (MB) radiofrequency ablation (RFA) is a common image-guided procedure to treat facetogenic low back pain. Recent anatomical literature has proposed a two-lesion RFA approach targeting the posterior portion of the lateral neck of superior articular process (SAP) and the superior aspect of the sub-mammillary fossa. The objectives of this report were to: 1) describe the novel lumbar MB RFA technique, 2) discuss the relevant anatomy, and 3) report pain relief outcomes in four patients who gave informed consent to be treated with the novel two-landmark lumbar MB RFA technique.

The effectiveness of sacral lateral branch radiofrequency neurotomy for posterior sacroiliac joint complex pain in patients selected by dual sacral lateral branch blocks; A real-world cohort study.

Background: Previous study of spinal neurotomy procedures indicates that stringent block selection improves outcomes. However, this pattern is not established for sacral lateral branch radiofrequency neurotomy (SLBRFN). Few SLBRFN studies have used stringent block selection criteria such as ≥80 % pain reduction following dual sacral lateral branch blocks (SLBB).

A description and outcome evaluation of sacrococcygeal joint radiofrequency neurotomy for treatment of chronic coccydynia - A dorsal approach.

Background: Coccydynia is a condition characterized by pain and tenderness in the coccyx region of the spine. Chronic coccydynia (≥3-months) management remains a clinical challenge. Radiofrequency neurotomy (RFN) targeting the sacrococcygeal joint (SCJ) and/or 1st intercoccygeal joint (ICJ) margins has emerged as an alternative, minimally invasive intervention for refractory coccydynia.

Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control study.

Background: The HVTN 705 Imbokodo trial of 2636 people without HIV and assigned female sex at birth, conducted in southern Africa, evaluated a heterologous HIV-1 vaccine regimen: mosaic adenovirus 26-based vaccine (Ad26.Mos4.HIV) at Months 0, 3, 6, 12 and alum-adjuvanted clade C gp140 at Months 6, 12.

Can ultrasound-guided medial branch blocks be used to select patients for cervical facet joint radiofrequency neurotomy? A matched retrospective cohort validation study.

Background: Medial branch blocks are used to select patients for cervical facet joint radiofrequency neurotomy (CRFN). Blocks are typically performed under fluoroscopic guidance (ie, fluoroscopy-guided blocks [FLBs]). The validity of ultrasound-guided blocks (USBs) is not well established.

Mesenchymal stem cells for chronic knee pain secondary to osteoarthritis: A systematic review and meta-analysis of randomized trials.

Objective: To assess the effectiveness of mesenchymal stem cells (MSCs) for chronic knee pain secondary to osteoarthritis (OA).

Methods: We searched MEDLINE, EMBASE, CINAHL, and Cochrane Central to September 2023 for trials that (1) enrolled patients with chronic pain associated with knee OA, and (2) randomized them to MSC therapy vs. placebo or usual care.

The Effect of Knee Height Asymmetry on Gait Biomechanics.

Background: Though the primary goal for limb length discrepancy (LLD) management is to equalize the leg lengths, symmetry between corresponding long bones is usually not achieved, leading to knee height asymmetry (KHA). To date, there is minimal information on what effect KHA has on gait biomechanics and joint loading. Thus, the purpose of this study is to determine the impact of KHA on gait biomechanics.

Assessment of the comparative agreement between chest radiographs and CT scans in intensive care units.

Purpose: Chest radiographs in critically ill patients can be difficult to interpret due to technical and clinical factors. We sought to determine the agreement of chest radiographs and CT scans, and the inter-observer variation of chest radiograph interpretation, in intensive care units (ICUs).

Methods: Chest radiographs and corresponding thoracic computerised tomography (CT) scans (as reference standard) were collected from 45 ICU patients.

Directing the migration of serum-free, -expanded Vγ9Vδ2 T cells.

Vγ9Vδ2 T cells represent a promising cancer therapy platform because the implementation of allogenic, off-the-shelf product candidates is possible. However, intravenous administration of human Vγ9Vδ2 T cells manufactured under good manufacturing practice (GMP)-compliant, serum-free conditions are not tested easily in most mouse models, mainly because they lack the ability to migrate from the blood to tissues or tumors. We demonstrate that these T cells do not migrate from the circulation to the mouse bone marrow (BM), the site of many malignancies.

The effectiveness and predictive factors of Sacroiliac Joint Radiofrequency Neurotomy success - A retrospective cohort study.

Background: The Sacroiliac Joint (SIJ) accounts for 10-27% of lower back pain. Radiofrequency neurotomy (RFN) is commonly utilized for refractory pain. Outcomes are variable and may be related to patient selection and procedural technique differences.

Derivation of a clinical decision rule for a bone marrow aspirate concentrate injection in knee osteoarthritis.

To develop a simple clinical decision rule (CDR) to identify people with knee osteoarthritis who are likely or unlikely to benefit from bone marrow aspirate concentrate (BMAC) injection. A total of 92 people with clinical and radiographic evidence of refractory knee osteoarthritis received a single intra-articular (IA) BMAC injection. Multiple logistic regression analysis was used to determine which combination of risk factors predicted BMAC responsiveness.

Cervical facet joint platelet-rich plasma in people with chronic whiplash-associated disorders: A prospective case series of longer term 6- and 12- month outcomes.

Objective: To explore the 6- and 12-month effectiveness of a single autologous injection of platelet-rich plasma (PRP) in cervical facet joints of people with chronic WAD and facet-mediated pain.

Design: A prospective case series of people with chronic whiplash-associated disorders and cervical facet joint mediated pain in a community setting.

Interventions: We investigated 44 consecutive people who underwent cervical facet joint PRP ( ​± ​adjunct physiotherapy) between 2019 and 2021, selected for PRP based on 80% relief following single diagnostic medial branch blocks or 50% relief and a significant improvement in performing a previously limited activity of daily living.

Outcomes of Total Knee and Hip Arthroplasty in Patients With Perioperative Thrombocytopenia.

Background: Thrombocytopenia is an abnormally low level of blood platelets (less than 150,000/mL) resulting in an increased risk for bleeding. Typically, patients with platelet levels below 50,000/mL should delay arthroplasty or be transfused with platelets before surgery. However, existing studies are mixed regarding the effects of more moderate thrombocytopenia in terms of total knee and hip arthroplasty outcomes.

Assessing Leg Length and Offset in Anterior Total Hip Arthroplasty: Overlay Versus AP Pelvis Intraoperative Radiographic Techniques: A Retrospective Cohort Study.

Introduction: Two intraoperative radiographic techniques to determine leg length and offset during anterior total hip arthroplasty (THA) are the AP pelvis and overlay techniques. The AP pelvis method measures LLDs and offset using AP fluoroscopic images, whereas the overlay method uses printed images of the native and replaced hips. The purpose of this study was to compare these techniques regarding clinical and radiographic LLD and offset discrepancies.

Using sketchnoting as a revision aid with forensic students.

The concept of Sketchnoting was first introduced by Mike Rhode as a means of capturing information in a visual form using a combination of the visual and words. Within Higher Education a Sketchnote can be used to record or summarise key points from a body of information using a combination of words, simple pictures, layout and graphics. Creating a Sketchnote allows a student to be able summarise key facts from a presentation, journal article, book or practical session in a visual manner that is easier to recall at a later time.

Understanding Attitudes, Beliefs, Behaviors, and Barriers to Hearing Loss Care Among Hispanic Adults and Caregivers.

While 9.5 million U.S.

A Multi-Dimensional Examination of Foraging Habitat Use by Gray Whales Using Long Time-Series and Acoustics Data.

Gray whales () show high site fidelity to feeding and breeding areas. The whales' annual cycle could be learned or be driven by factors such as prey abundance or ocean conditions. Long-term line transect and photo-identification data were analyzed to consider intra- and inter- annual patterns of habitat use and the underlying drivers for foraging areas in Clayoquot Sound, British Columbia.

Liana functional assembly along the hydrological gradient in Central Amazonia.

Soil hydrology, nutrient availability, and forest disturbance determine the variation of tropical tree species composition locally. However, most habitat filtering is explained by tree species' hydraulic traits along the hydrological gradient. We asked whether these patterns apply to lianas.

The Association Between Sleep Disturbance and Health Outcomes in Chronic Whiplash-associated Disorders: A Series of Mediation Analyses.

Objectives: To investigate the association between sleep disturbance and clinical features of chronic whiplash-associated disorders (WAD). We also aimed to use a bootstrapped mediation analysis approach to systematically examine both direct and indirect pathways by which sleep disturbance may affect chronic pain and functional status.

Materials And Methods: One hundred sixty-five people (63% female) with chronic WAD and not taking medications for sleep disturbance completed questionnaires evaluating sleep disturbance, pain intensity, pain interference, disability, physical and mental health quality of life, stress, anxiety, depression, pain catastrophizing, and posttraumatic stress severity.

Prospective Within Subject Comparison of Fluoroscopically Guided Lumbosacral Facet Joint Radiofrequency Ablation Using a Multi-Tined (Trident) Versus Conventional Monopolar Cannula.

Background: Radiofrequency ablation (RFA) for the lumbar facet joints has demonstrated efficacy in the management of chronic low back pain. The traditional technique uses a conventional monopolar (CM) cannula placed parallel to the putative nerve to produce a thermal lesion resulting in pain relief of the facet joints. A new multi-tined (MT) cannula has come onto the market that allows targeting the putative nerve using a perpendicular to the nerve approach.

Radiofrequency Ablation of the Infrapatellar Branch of the Saphenous Nerve for the Treatment of Chronic Anterior Inferomedial Knee Pain.

Intro: Genicular nerve radiofrequency ablation (GNRFA) is an effective treatment for chronic knee pain related to osteoarthritis. It is often utilized when conservative management has failed and patients wish to avoid arthroplasty, are poor surgical candidates due to comorbid medical conditions, or in those suffering from persistent pain after arthroplasty. The classic targets for GNRFA include the superior lateral genicular nerve, superior medial genicular nerve, and inferior medial genicular nerve but multiple anatomic studies have demonstrated additional sensory innervation to the knee.

Ultrasound-guided radiofrequency Ablation for SI joint pain:An observational study.

Objective: An ultrasound (US) guided RFA technique for the SIJ, utilizing bipolar RF cannula placements along the lateral sacral crest (LSC), has been proposed in anatomical studies. This study evaluated changes in pain intensity, function and quality of life following this technique.

Methods: Patients achieving ≥50% pain relief on two blocks (one FL- and one US-guided) were included.

An assessment of the minimal clinically important difference for the pain disability quality-of-Life Questionnaire-Spine.

Objective: The Pain Disability Quality-Of-Life Questionnaire-Spine (PDQQ-S) is a validated six question patient reported outcome measure designed for usage in minimally invasive spine intervention. The purpose of this study was to determine the Minimal Clinically Important Difference (MCID) for the PDQQ-S.

Design: Retrospective single arm cohort study involving 411 patients who had undergone lumbar facet and/or sacroiliac joint RFN and had completed pre-and 3-month post RFN PDQQ-S.

Dissecting the cellular components of γδ T cell expansions to optimize selection of potent cell therapy donors for neuroblastoma immunotherapy trials.

γδ T lymphocytes represent an emerging class of cellular immunotherapy with preclinical promise to treat cancer, notably neuroblastoma. The innate-like immune cell subset demonstrates inherent cytoxicity toward tumor cells independent of MHC recognition, enabling allogeneic administration of healthy donor-derived γδ T cell therapies. A current limitation is the substantial interindividual γδ T cell expansion variation among leukocyte collections.