[FEDERAL CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS, PREVENTION AND TREATMENT OF PNEUMOCONIOSIS].

The purpose of development of this clinical practice guidelines was to provide evidence-based protocols that help the practitioner and the patient make the right decision for the health assessment, treatment and prevention of pneumoconiosis. Pneumoconiosis is the interstitial lung disease of occupational origin caused by prolonged inhalation of inorganic dust, characterized by chronic diffuse aseptic inflammation in lung tissue with the development of pulmonary fibrosis. Currently, thereare no treatment that provide a cure pulmonary fibrosis and changes in the dynamics of decline in lung function.

[Occupational lung diseases caused by exposure to chrysotile asbestos dust and the preventive measures].

To reveal major principles in system of occupational lung diseases prevention among workers engaged into extraction and usage of chrysotile asbestos, the authors specified main criteria for diagnosis of asbestos-related pulmonary diseases and signs of exposure to chrysotile dust, with identification of risk groups for occupational diseases development. The authors formulated main principles of prevention and rehabilitation for workers with asbestos-related pulmonary diseases. Special attention was paid to harmonization of all medical and technical measures aimed at prevention and liquidation of occupational asbestos-related diseases.

[Contemporary aspects of maintenance and promotion of health of the workers employed at the aluminum production enterprises].

The exposure of the combined occupational hazards on the workers of aluminum plants results in the development of the occupational chronic diseases of bronchopulmonary and bone systems and oncopathology. Pathogenetic mechanisms of the toxic exposure of fluorides on the body as well as molecular and cellular structures are presented.

[Peculiarities of pulmonary X-ray changes due to exposure to welding aerosol].

The authors first evaluated pulmonary X-ray changes in contemporary pneumoconiosis types and hypersensitivity pneumonoitis, both caused by exposure to welding aerosol.

[Pathomorphosis of contemporary forms of occupational diseases].

Studies on pathogenetic mechanisms of development, formation and course of occupational diseases revealed pathomorphosis of major specification forms (diseases of bronchopulmonary system, skin, nervous system, locomotory apparatus). Developing pathomorphosis of occupational and occupationally mediated diseases is caused by changed work conditions, lower acting concentrations and levels of occupational factors, influence of harmful ecologic factors, metabolic features, immune state, individual sensitivity to occupational and environmental factors.

[Clinical and immunologic aspects of occupational hypersensitivity pneumonitis variants].

Complex clinical examination of patients with occupational hypersensitivity pneumonitis caused by inorganic, organic and mixed dust helped to spicify variants of the disease--with prevailing bronchial asthma, chronic obstructive bronchitis, recurrent pneumonia, chronic respiratory failure.

[Preliminary and periodic medical examinations of asbestos production workers].

The article covers general principles of health care for workers in various industries associated with contact to dust containing asbestos. The authors present main requirements of legal papers basing concepts that determine role of employers, trade unions, workers and medical officers in creation and maintenance of safe work conditions, in establishment of prophylactic, therapeutic and rehabilitation measures.

[Clinico-roentgenological and occupational correlations as a method of revealing the dose-effect dependence in the development of chrysotile-asbestos fibrosis].

For understanding up-to-date situation with fibrosis caused by chrysotile-asbestos, the authors conducted X-ray and hygienic studies in 2 enterprises extracting and enriching asbestos--"Tuvaasbest" JSC and "Orenbourgasbest" JSC. Authors followed correlation between diffuse pulmonary changes and length of service, dust load and cumulative exposure dose of respirable fibers. The strongest correlation was demonstrated for dust load.

[Chrysotile asbestos in Russia: certain results and promising research directions].

The article summarizes studies carried in RAMSc Research Institute for Occupational Medicine on chrysotile asbestos. Not denying potential carcinogenicity characteristic for all kinds of asbestos, those studies stress low biologic aggression of chrysotile asbestos during occupational exposure, even if the excessive MAC is demonstrated formerly in asbestos industry enterprises. Work with chrysotile asbestos, as every one in mining industry, requires not ban, but accomplishment of proper measures aimed to prevent pneumoconiosis and dust bronchitis.

[The classification of pneumoconioses].

The article deals with analysis of scientific data concerning etiology, pathogenesis, clinical and roentgenologic manifestations, morphologic appearances and other aspects to precise and refine the former idea of pneumoconioses. The authors present the main principles for improved classification of pneumoconioses.

[Resistance of the functional systems of the smooth muscle cells of isolated myometrium to long-term incubation in Ringer-Locke solution at 4 degrees C].

Contractile effects of adrenaline, acethylcholine and hyperpotassium solution on the isolated myometrium strips (non-pregnent rats, and women; pregnant rabbits, cats, and women) are studied. The amplitudes of these contractile effects were seen decreasing if the strips were previously immersed in the Ringer-Lokk solution at 4 degrees C 5--9 days prior to observation.