The significance of monitoring respiratory sample cultures and polymerase chain reaction tests for detecting bacterial pathogens in severely and critically ill patients with COVID-19.

Background: Bacterial superinfection is one of the most common and potentially lethal complications in severely and critically ill patients with COVID-19.

Objectives: To determine the colonisation time frame and the spectrum of potential bacterial pathogens in respiratory samples from patients with severe and critical COVID-19, using routine culture and polymerase chain reaction (PCR) tests.

Methods: A prospective observational study was conducted on patients aged ≥18 years with confirmed severe and critical COVID-19 who were admitted to or transferred to the intensive care unit (ICU).

[Bacteriophages in complex treatment of septic diseases of the hand].

Objective: To evaluate the effectiveness of bacteriophages in complex surgical treatment of septic diseases of the hand.

Material And Methods: We analyzed treatment outcomes in 111 patients with septic diseases of the hand (septic arthritis, tendovaginitis, phlegmon). Surgical treatment was finished by primary sutures and drainage.

Identification of risk factors and development of a predictive model for bloodstream infection in intensive care unit COVID-19 patients.

Objectives: To identify risk factors for nosocomial bloodstream infections (BSIs) in intensive care unit (ICU) patients with COVID-19 and to build a predictive model for BSIs.

Patients And Methods: The retrospective case-control study included 236 ICU COVID-19 patients with BSIs group and 234 patients in the control group. Demographic and laboratory data, comorbidities, drug use, invasive procedures and identified pathogens were recorded separately for patients directly admitted and transferred to ICU.

Unexpected clinical case of infectious endocarditis in a patient with iv drug abuse: why epidemiological history matters.

Introduction: Right-sided lesions caused by staphylococci are the most common clinical entity of infectious endocarditis (IE) among iv drug abusers. But some aspects of the epidemiological history are critical in terms of early detection of uncommon pathogens.

Case Report: We describe a clinical observation of native aortic valve IE caused by in a 37-year-old female with a history of heroin addiction, alcohol abuse and liver cirrhosis.

[Clinical efficacy of the antimicrobial drug furamag in nosocomial urinary tract infections].

Aim: To evaluate the efficacy of the combined drug furamag (furasidine potassium and magnesium hydroxycarbonate) in combination with the third-generation cephalosporin cefotaxime versus cephalosporin monotherapy for nosocomial urinary tract infections (NUTI).

Subjects And Methods: The randomized open-label comparative parallel group clinical trial enrolled 52 male and female patients aged over 18 years with a documented diagnosis of NUTI. Group 1 (a study group) took oral furamag 300 mg/day in combination with intravenous cefotaxime 6 g/day; Group 2 (a control group) received cefotaxime monotherapy.

[Degradation of purines in leukocytes in acute nonlymphoblastic leukemias].

Activities of the enzymes, responsible for degradation of purine nucleotides in leukocytes, were distinctly dissimilar in M1, M2, M4 and M6 variants of acute non-lymphoblastic leukosis studied in 34 patients. Differentiation of leukemic cells was shown to be due to alterations in activity of adenosine deaminase and purine nucleoside phosphorylase, which were oppositely directed as compared with those observed in lymphoblasts under conditions of acute lymphoblast leukosis. Evaluation of activities of adenosine deaminase, purine nucleoside phosphorylase and 5'-nucleotidase is of importance for characteristics of individual variants of acute non-lymphoblastic leukosis and for elucidation of the state of leukemic clone differentiation, which may affect the efficiency of the therapeutic measures used.