Case Report: Beyond the Blood-retina Barrier: Intravitreal Caspofungin for Fungal Endophthalmitis.

Significance: Two fungal endophthalmitis cases demonstrate safety and efficiency of intravitreal caspofungin as a new therapy option in fungal endophthalmitis.

Purpose: The purpose of this study was to evaluate the intravitreal application of caspofungin for the treatment of fungal endophthalmitis because rising resistance to voriconazole and amphotericin B leads to a need for new antifungal therapy options.

Case Report: Initially, both patients with fungal endophthalmitis underwent pars plana vitrectomy.

[Chronic bilateral orbital tumors in IgG4-related disease].

Background: The IgG4-related disease describes a new multisystem disorder, which can also be manifested in the orbit. This syndrome is characterized by a multifocal chronic fibroinflammation with high levels of plasma cells expressing IgG4.

Case Report: This article reports the case of a patient with advanced bilateral tumors of the upper eyelid and orbit.

Evaluation of interface quality in organ-cultured lamellar corneal transplants.

Background: With increasing numbers of lamellar keratoplasties, eye banks are challenged to deliver precut lamellar donor tissue. In Europe, the most common technique of corneal storage is organ culture which requires a deswelling process before surgical processing. The aim of this study was to investigate the influence of different deswelling times on the cutting plane quality after microkeratome-assisted lamellar dissection.

Intracameral injection of bevacizumab for the treatment of neovascular glaucoma.

Purpose: To assess the duration of the effect of intracameral bevacizumab in patients presenting with rubeosis iridis and neovascular glaucoma (NVG).

Methods: Retrospective analysis of 24 consecutive eyes of 24 patients with decompensated NVG (> 21 mm Hg) treated with a single intracameral injection of bevacizumab over a minimum follow-up of 6 months. The endpoint of the study was the need for retreatment due to recurrence of raised intraocular pressure (IOP).

Functional outcome of indocyanine green-assisted macular surgery: 7-year follow-up.

Purpose: To evaluate the long-term functional results after surgery for macular pucker and macular holes with indocyanine green (ICG) staining of the internal limiting membrane.

Methods: Long-term functional and anatomical outcomes of 16 eyes of 16 patients were evaluated for 7.3 years after ICG-assisted macular surgery.

Corneal architecture of femtosecond laser and microkeratome flaps imaged by anterior segment optical coherence tomography.

Purpose: To assess and compare the morphology of laser in situ keratomileusis flaps (LASIK) created by a 60 kHz femtosecond laser and a mechanical microkeratome.

Setting: Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.

Methods: Anterior segment optical coherence tomography (AS-OCT) (Visante) was used to assess 1 week postoperatively the morphology of 20 LASIK flaps created with the IntraLase femtosecond laser or the Zyoptix XP microkeratome.

Anterior optic neuropathy associated with adalimumab.

Purpose: Our purpose was to report a case of anterior optic neuropathy with pupillary edema in a patient treated with the TNF-alpha-antagonist adalimumab.

Methods: We report the case of a 60-year-old woman with optic neuropathy in 1 eye after 6 months of treatment with adalimumab.

Results: The patient developed decreased visual acuity of the left eye.

Macular thickness after uneventful cataract surgery determined by optical coherence tomography.

Background: Using standardized macular optical coherence tomography (OCT) in the postoperative period, subclinical changes in macular thickness can be detected. With this method, postoperative development of macular thickness in healthy eyes is evaluated. The repeatability of the method and the influence of selected surgical (phaco time and phaco energy) and biometric parameters (axial length and anterior chamber depth) on the results were assessed.