[Ototoxicity caused by anti-epileptic drugs].

According to the literature, a number of anti-epileptic drugs (AEDs) have an ototoxic effect. The mechanism of hearing dysfunction due to the use of AEDs is not well known. The main clinical manifestations of the cochleotoxic effect of the drugs are: tinnitus, sensorineural hearing loss, impaired pitch perception, hyperacusis.

[Brain microstructural abnormalities assessed by diffusion kurtosis MRI in patients with focal temporal lobe epilepsy].

Objective: To study microstructural abnormalities in epileptogenic focus and in mirror region by diffusion kurtosis (DK) MRI in patients with focal temporal lobe epilepsy.

Material And Methods: The main group included 12 patients (mean age 35 [30.5; 39.

[The results of a multicenter open observational study of the efficacy and safety of the dietary supplement Neururidine N in patients with acute nonspecific lower back pain in daily outpatient practice (the NEURO-N study)].

Objective: To study the efficacy and safety of the use of high (200 mg) doses of uridine monophosphate in combination with choline (dietary supplement, dietary supplement, Neururidine N) in the treatment of patients with nonspecific back pain.

Material And Methods: An open observational study was conducted, which included 101 patients with acute PB; group 1 included 65 patients who received Neurouridine N (1 caps/day) meloxicam (7.5-15 mg/day) and meloxicam (7.

[EEG changes in patients with Alzheimer's disease].

The prevalence of cognitive impairment is steadily increasing compared to previous years. According to the World Health Organization, the number of people living with dementia will increase reaching 82 million in 2030 and 152 million in 2050. The most common cause is Alzheimer's disease (AD).

Continuous cardiac monitoring in epilepsy: an implantable loop manual activation algorithm for improving ECG signal acquisition accuracy.

Background: The muscle artifacts, caused by prominent muscle contractions, mimicking cardiac arrhythmias, might compromise the ECG signal quality and the implantable loop recorder memory capacity in patients with epilepsy. We developed an epileptic seizures clinical pattern-based implantable loop recorder manual activation algorithm, presenting its real-world efficacy here.

Methods: One hundred ninety-three patients (18-60 years) with drug-resistant focal epilepsy were consecutively enrolled and underwent a subcutaneous loop recorder implantation.

[Epilepsy syndromes associated with hearing loss].

Patients with epilepsy who have also hearing loss represent a distinct group of patients, often with aggravated medical history, comorbidities and high potential for disability. The etiopathogenetic factors of epilepsy and hearing loss may be common to these conditions (neuroinfections, craniocerebral injuries, cerebral circulatory disorders, perinatal pathology, etc.).

[COVID-19-associated damage of the peripheral nervous system].

Based on the available literature data, the article discusses the prevalence of various forms of damage of the peripheral nervous system in COVID-19 and in the post-COVID period. Information about the clinical features and the course of individual cranial neuropathies, chronic dysimmune neuropathies, Guillain-Barré syndrome, drug-induced neuropathies, fine fiber neuropathy, myasthenia gravis and polyneuropathy of critical conditions was systemized in the context of coronavirus infection. SARS-CoV-2 can trigger various stages of pathogenesis, including neuroimmune ones, which cause long-term consequences of COVID-19, including those associated with the damage of the peripheral nervous system.

[Clinical results and prospects for the use of phenosanic acid in patients with focal epilepsy].

Objective: To study the efficacy and safety of using a new original synthetic antioxidant - phenosanic acid as an adjunct therapy in patients with focal epilepsy.

Material And Methods: A randomized, double-blind, placebo-controlled, parallel-group study evaluated the efficacy and safety of phenosanic acid as an adjunct therapy to basic antiepileptic drugs in 120 patients with focal epilepsy. Primary purpose: to study the dynamic of seizure frequency.

[Healthcare of Russia today. Epileptological service].

Objective: To examine the state of the epileptological service in Russia by conducting a survey of epileptologists working in different regions of the Russian Federation.

Material And Methods: To assess the structure and mechanisms of the antiepileptic service in the Russian Federation, the Russian League Against Epilepsy (RLAE) offered a questionnaire to 63 epileptologists, which has been answered by 37 epileptologists from 28 regions of the country.

Results And Conclusion: Among the respondents, 43% are focused on the care of outpatients, 35% work both in outpatient and inpatient appointments, 22% work only in hospitals.

High-fidelity laser-free universal control of trapped ion qubits.

Universal control of multiple qubits-the ability to entangle qubits and to perform arbitrary individual qubit operations-is a fundamental resource for quantum computing, simulation and networking. Qubits realized in trapped atomic ions have shown the highest-fidelity two-qubit entangling operations and single-qubit rotations so far. Universal control of trapped ion qubits has been separately demonstrated using tightly focused laser beams or by moving ions with respect to laser beams, but at lower fidelities.

Motional Squeezing for Trapped Ion Transport and Separation.

Transport, separation, and merging of trapped ion crystals are essential operations for most large-scale quantum computing architectures. In this Letter, we develop a theoretical framework that describes the dynamics of ions in time-varying potentials with a motional squeeze operator, followed by a motional displacement operator. Using this framework, we develop a new, general protocol for trapped ion transport, separation, and merging.

["Ictal" Bradyarrhythmias in Patients with Drug-Resistant Epilepsy: Results of Long-Term Heart Rhythm Monitoring].

Aim      To determine the type and incidence of ictal bradyarrhythmias in patients with drug-resistant types of epilepsy by long-term electrocardiogram (ECG) monitoring.Material and methods  Subcutaneous ECG monitors programed for recording pauses >3 sec and episodes of bradycardia ≤45 bpm were implanted in 193 patients with persistent epileptic seizures without organic pathology of the myocardium. Recording was activated by the patient/family at the onset of epileptic seizure.

Cardiac arrhythmias and sudden unexpected death in epilepsy: Results of long-term monitoring.

Background: Cardiac rhythm and conduction disorders are common in patients with epilepsy and are presumably one of the leading causes of sudden unexpected death. There are only a few published reports on ictal cardiac arrhythmias detected by continuous monitoring, and the majority had a small sample size.

Objective: The aim of this study was to evaluate the frequency and type of cardiac arrhythmias recorded by an implantable loop recorder in patients with drug-resistant epilepsy.

[The effectiveness of antiepileptic therapy in patients with epileptic syndromes associated with myoclonic seizures].

Objective: To evaluate the effectiveness of antiepileptic therapy of epileptic syndromes associated with myoclonic seizures.

Material And Methods: One hundred and three patients with epilepsy, in whom myoclonic seizures were identified during the observation, were examined. The observed myoclonic seizures entered the structure of 11 different epileptic syndromes.

Versatile laser-free trapped-ion entangling gates.

We present a general theory for laser-free entangling gates with trapped-ion hyperfine qubits, using either static or oscillating magnetic-field gradients combined with a pair of uniform microwave fields symmetrically detuned about the qubit frequency. By transforming into a 'bichromatic' interaction picture, we show that either or geometric phase gates can be performed. The gate basis is determined by selecting the microwave detuning.

Quantum-enhanced sensing of a single-ion mechanical oscillator.

Special quantum states are used in metrology to achieve sensitivities below the limits established by classically behaving states. In bosonic interferometers, squeezed states, number states and 'Schrödinger cat' states have been implemented on various platforms and have demonstrated improved measurement precision over interferometers using coherent states. Another metrologically useful state is an equal superposition of two eigenstates with maximally different energies; this state ideally reaches the full interferometric sensitivity allowed by quantum mechanics.

Quantum amplification of mechanical oscillator motion.

Detection of the weakest forces in nature is aided by increasingly sensitive measurements of the motion of mechanical oscillators. However, the attainable knowledge of an oscillator's motion is limited by quantum fluctuations that exist even if the oscillator is in its lowest possible energy state. We demonstrate a technique for amplifying coherent displacements of a mechanical oscillator with initial magnitudes well below these zero-point fluctuations.

Trapped-Ion Spin-Motion Coupling with Microwaves and a Near-Motional Oscillating Magnetic Field Gradient.

We present a new method of spin-motion coupling for trapped ions using microwaves and a magnetic field gradient oscillating close to the ions' motional frequency. We demonstrate and characterize this coupling experimentally using a single ion in a surface-electrode trap that incorporates current-carrying electrodes to generate the microwave field and the oscillating magnetic field gradient. Using this method, we perform resolved-sideband cooling of a single motional mode to its ground state.

[Assessment of quality of life and treatment adherence in patients with dizziness treated with vasobral].

Aim: To study indicators of quality of life and adherence to treatment with vazobral in patients with dizziness of vascular genesis.

Material And Methods: Vazobral was administered to 330 patients with vertigo due to cerebrovascular disease for 3 months during a non-inferiority, open-label study. Quality of life (measured using VAS and the second part of the EQ-5D questionnaire), severity and frequency of dizziness attacks (using VAS), the overall effectiveness of treatment on the basis of objective (according to the doctor) and subjective (using CGI) assessments, treatment adherence were evaluated.

[The possibility of using combination therapy in patients with chronic cerebral ischemia].

Aim: To evaluate the efficacy and tolerability of mexiB 6 and vinpotropil 10/800 in patients with chronic cerebral ischemia.

Material And Methods: The study included 30 outpatients with chronic cerebral ischemia, 1-2 stages. The average age was 55,2±10,04 years.

[Indication of antiepileptic drugs to patients with epilepsy: results of the survey of neurologists].

Aim: To study knowledge and opinions of neurologists about priorities in using antiepileptic drugs (AEP).

Material And Methods: Eighty-one neurologists from Moscow and surrounding regions were surveyed to identify the factors that influenced the choice of AEP.

Results And Conclusion: Valproic acid was the most frequently used drug followed by levetiracetam and carbamazepine, which reflected the overall picture of PEP indication in patients with epilepsy in the Russian population.

[Epileptic syndromes in childhood associated with secondary generalized tonic-clonic seizures].

Aim: To study a group of patients with secondary generalized tonic-clonic seizures (SGTCS) in view of nosology, medical history, clinical, electroencephalographic and neuroimaging features.

Material And Methods: The study included 471 patients, 244 (51.8%) men and 227 (48.

A retrospective, multicentre study of perampanel given as monotherapy in routine clinical care in people with epilepsy.

Purpose: Perampanel is approved for adjunctive treatment of focal seizures, with or without secondarily generalised seizures, and for primary generalised tonic-clonic seizures in people with epilepsy aged ≥12 years. Perampanel was recently approved for monotherapy use for partial seizures in the United States. This study provides insight into the feasibility of perampanel monotherapy in real-world settings.