The changes in the expression levels of β-catenin gene in pre- and post- Kidney Transplants.

Purpose: Wnt signaling is an important pathway in kidney development and disease. We aimed to establish the levels of β-catenin expression in CD4 T cells before and after renal transplantation and to associate it with the form of transplant type, rejection, and graft dysfunction.

Methods: CD4 T cells were isolated from patients before and after kidney transplantation and their purity was confirmed by flow cytometer.

Consideration of IL-2, IFN-γ and IL-4 expression and methylation levels in CD4+ T cells as a predictor of rejection in kidney transplant.

Kidney transplantation is the certain treatment for the end-stage-kidney disease patients. However after transplantation, allograft rejection or graft dysfunction are serious problems which the patients can be encountered. In several studies new biomarkers to predict rejection episodes tried to be evaluated and cytokines are thought to be one of these biomarkers.