T-Cell Composition of the Lymph Node Is Associated with the Risk for Early Rejection after Renal Transplantation.

Background: The T-cell composition within the lymph node (LN) of end-stage renal disease (ESRD) patients differs from the composition within the circulation. Activation of the alloreactive T-cell response within secondary lymphoid organs is important after organ transplantation. However, to date no data are present on LN T-cell subsets and the risk for acute rejection after kidney transplantation.

Protective Cytomegalovirus (CMV)-Specific T-Cell Immunity Is Frequent in Kidney Transplant Patients without Serum Anti-CMV Antibodies.

The absence of anti-cytomegalovirus (CMV) immunoglobulin G (IgG) is used to classify pretransplant patients as naïve for CMV infection (CMV patients). This study assessed whether pretransplant CMV-specific T-cell immunity exists in CMV patients and whether it protects against CMV infection after kidney transplantation. The results show that CMV-specific CD137IFNγCD4 and CD137IFNγCD8 memory T cells were present in 46 and 39% of CMV patients ( = 28) although at much lower frequencies compared to CMV patients (median 0.

Loss of CD28 on Peripheral T Cells Decreases the Risk for Early Acute Rejection after Kidney Transplantation.

Background: End-stage renal disease patients have a dysfunctional, prematurely aged peripheral T-cell system. Here we hypothesized that the degree of premature T-cell ageing before kidney transplantation predicts the risk for early acute allograft rejection (EAR).

Methods: 222 living donor kidney transplant recipients were prospectively analyzed.

Novel biomarkers for the prediction of acute kidney injury in patients undergoing liver transplantation.

Aim: Because of the delayed rise of serum creatinine concentrations, novel biomarkers such as NGAL, GST and KIM-1 are proposed to detect acute kidney injury (AKI). In this study we evaluated these biomarkers.

Materials & Methods: Twenty-six consecutive adult liver transplantations were evaluated.