Publications by authors named "Buqing Fu"
Aneuploidy underlies brefeldin A-induced antifungal drug resistance in .
Front Cell Infect Microbiol
July 2024
Article Synopsis
- * It reveals that exposure to Brefeldin A (BFA), which induces endoplasmic reticulum stress, leads to the formation of aneuploidy, specifically disomy in certain chromosomes, affecting drug resistance patterns.
- * The study suggests that disomy of chromosome 1 causes cross-resistance to fluconazole and 5-flucytosine while increasing sensitivity to amphotericin B, indicating BFA could accelerate the emergence of drug resistance through genomic changes.
Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder, which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed cell death characterized by NLR Family Pyrin Domain Containing 3 (NLRP3)-dependent, IL-1β, IL-18 and Gasdermin D. Salidroside (Sal) has been reported to have neuro-protective effect.
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