Natural History and Real-World Treatment Outcomes for Patients With NSCLC Having Exon 20 Insertion Mutation: An International Association for the Study of Lung Cancer-American Society of Clinical Oncology CancerLinQ Study.

Introduction: EGFR exon 20 insertion (ex20ins) mutations account for approximately 10% of EGFR mutations in lung adenocarcinoma. Patients with ex20ins mutation do not respond to standard EGFR tyrosine kinase inhibitor therapy. In this work, we analyzed the characteristics, treatment patterns, and outcomes in this subgroup of patients with NSCLC.

Standardization of Emergency Department Clinical Note Templates: A Retrospective Analysis across an Integrated Health System.

Background And Objective:  Clinical documentation is essential for conveying medical decision-making, communication between providers and patients, and capturing quality, billing, and regulatory measures during emergency department (ED) visits. Growing evidence suggests the benefits of note template standardization; however, variations in documentation practices are common. The primary objective of this study is to measure the utilization and coding performance of a standardized ED note template implemented across a nine-hospital health system.

5-Methylheptadecane: Sex Pheromone of the Broom Twig Miner, Leucoptera Spartifoliella, a Biological Control Agent for the Scotch Broom.

The broom twig miner, Leucoptera spartifoliella (Hübner) is a highly specific biological control agent for the Scotch broom, Cytisus scoparius (L.). Cytisus scoparius has become a major invasive weed spreading in North America, South America, Australia and both the South and North Island of New Zealand, causing a major disturbance to the ecology of the area where it has been established.

The "hypopigmented" bitemark: a clinical and histologic appraisal.

So-called "hypopigmented" bitemark patterns, commonly seen but not limited to dark skinned individuals, can be of value in forensic investigations. The process of aging bitemarks observed on skin is controversial and without guidelines. This report analyzes tissue obtained from the site of a hypopigmented bitemark using special histochemical stains for the identification of melanin pigment, and a panel of immunohistochemical markers to aid in the aging process.

Influence of oral administration of kukoamine A on blood pressure in a rat hypertension model.

The benefits of lowering blood pressure (BP) are well established for the prevention of cardiovascular disease. While there are a number of pharmaceuticals available for lowering BP, there is considerable interest in using dietary modifications, lifestyle and behaviour changes as alternative strategies. Kukoamines, caffeic acid derivatives of polyamines present in solanaceous plants, have been reported to reduce BP.

N-(3-methylbutyl)butanamide: A novel amide in the venom of female social wasps, Vespula vulgaris.

In New Zealand's ancient Fuscospora spp. or beech forests, two invasive Vespula social wasps Vespula vulgaris (L.) and Vespula germanica (F.

Biocatalysts from cyanobacterial hapalindole pathway afford antivirulent isonitriles against MRSA.

The emergence of resistance to frontline antibiotics has called for novel strategies to combat serious pathogenic infections. Methicillin-resistant [MRSA] is one such pathogen. As opposed to traditional antibiotics, bacteriostatic anti-virulent agents disarm MRSA, without exerting pressure, that cause resistance.

A Stitch in Time Saves Clots: Venous Thromboembolism Chemoprophylaxis in Traumatic Brain Injury.

Background: Venous thromboembolism chemoprophylaxis (VTE-CHEMO) is often delayed in patients with traumatic brain injury because of the concern for intracranial hemorrhage (ICH) progression. We hypothesize that (1) late time to VTE-CHEMO (≥48 h) is associated with higher incidence of VTE, and (2) VTE-CHEMO use does not correlate with ICH progression.

Materials And Methods: This is a multiinstitutional retrospective study of patients with traumatic brain injury admitted between 2014 and 2016.

The prevalence of second canals in the mesiobuccal root of maxillary molars: A cone beam computed tomography study.

The aim of this study was to determine the prevalence of MB2 canals in permanent maxillary molars utilising CBCT; in patients attending a university hospital. A total of 200 patient scans, (100 female and 100 male patients), were enrolled in the study. In total, 800 teeth were analysed, and teeth with additional canals in their MB roots (MB2) were identified.

Mixed adenoneuroendocrine carcinoma of the tongue arising within a congenital enteric cyst.

Background: Primary intestinal-type adenocarcinoma of the tongue is rare. This represents the first reported case of a primary mixed adenoneuroendocrine carcinoma (MANEC) of the tongue arising within a congenital enteric cyst.

Methods: A 52-year-old man presented with a midline tongue mass that was connected to the mucosal surface with an epithelial-lined sinus tract.

EBV-positive mucocutaneous ulcer of the oral cavity associated with HIV/AIDS.

Objective: To present 2 cases of Epstein-Barr virus (EBV)-positive mucocutaneous ulcer of the oral mucosa in association with human immunodeficiency virus infection.

Study Design: Two recently diagnosed cases of EBV-positive mucocutaneous ulcer of the oral mucosa in patients with human immunodeficiency virus (HIV) were reviewed with regard to their clinical, histomorphologic, and immunophenotypic features.

Results: Both cases presented clinically as well-circumscribed ulcers that were histomorphologically characterized by dense superficial polymorphous inflammatory infiltrates.

Adenoid dysplasia of the oral mucosa.

Objective: To describe an unusual variant of oral epithelial dysplasia and to provide an appraisal of its immunohistochemical profile.

Study Design: An unusual form of epithelial dysplasia, which we have termed adenoid dysplasia, was evaluated for staining of cytokeratins AE1/AE3, vimentin, E-cadherin, and β-catenin. The immunohistochemical results were compared with those observed in moderate epithelial dysplasia, moderately differentiated squamous cell carcinoma, and acantholytic squamous cell carcinoma.

Comparative analysis of hapalindole, ambiguine and welwitindolinone gene clusters and reconstitution of indole-isonitrile biosynthesis from cyanobacteria.

Background: The hapalindole-type family of natural products is a group of hybrid isoprenoid-indole alkaloids, produced solely by members of the Subsection V cyanobacterial strains. This family broadly includes the hapalindoles, welwitindolinones, fisherindoles and ambiguines amongst others, all of which have an isonitrile- or isothiocyanate-containing indole alkaloid skeleton, with a cyclized isoprene unit. The hapalindoles are diversified into the welwitindolinones, fischerindoles and ambiguines through the employment of tailoring oxygenase, methyltransferase and prenyltransferase enzymes.

Amelogenesis imperfecta: a diagnostic and pathological review with case illustration.

Amelogenesis mperfecta is an inherited disorder of enamel development, which results n morphological defects of both the primary and secondary dentition, usually in the absence of systemic involvement. Mutational defects involving the genes that encode for enamel matrix proteins and proteinases are mplicated in this disorder. The phenotypic expression is variable, spanning a spectrum from barely discernible changes to severe aesthetic and functional enamel defects.

HIV/AIDS associated malignancies of the head and neck.

Patients with HIV/AIDS are at increased risk for the development of malignancy. Kaposi's sarcoma, non-Hodgkin's lymphoma and cervical carcinoma in women are regarded as AIDS-defining malignancies. The spectrum of malignancy is, however, changing, particularly where patients receive highly active antiretroviral therapy (HAART).

Oropharyngeal carcinoma: what the dentist should know.

HPV-related oropharyngeal carcinoma (OPC) is a clinically and molecularly distinct form of squamous cell carcinoma (SCC) which has recently shown a dramatc increase in global incidence. The aetiology, clinical presentation and overall prognosis differ from conventional tobacco and alcohol related SCC of the oral cavity. OPC is seen in a subset of younger predominantly male patients.

Clinical features of oral cancer.

Oral cancer (OC) is a major cause of global morbidity and mortality Squamous cell carcinoma accounts for more than 90% of oral malignancies and occurs most frequently in middle-aged to elderly patients who smoke and drink heavily. The overall outlook for patients diagnosed with oral squamous cell carcinoma (OSCC) remains poor, largely due to late clinical presentation. Early lesions are frequently undetected due to the lack of accompanying symptoms.

Drosophila PRL-1 is a growth inhibitor that counteracts the function of the Src oncogene.

Phosphatase of Regenerating Liver (PRL) family members have emerged as molecular markers that significantly correlate to the ability of many cancers to metastasize. However, contradictory cellular responses to PRL expression have been reported, including the inhibition of cell cycle progression. An obvious culprit for the discrepancy is the use of dozens of different cell lines, including many isolated from tumors or cultured cells selected for immortalization which may have missing or mutated modulators of PRL function.