Recurrences of oral cancer due to discontinuous periosteal involvement.

In order to determine whether an in-transit metastasis on the lingual periosteum might be a cause for recurrences of oral cancer, a retrospective review of 576 surgically treated patients was undertaken. In two patients, a simultaneous discontinuous involvement of the periosteum was verified. In 91 patients, a local recurrence was found, and, in 19, it was explained by periosteal involvement.

[Comparison of clinical and histopathological diagnosis in oral surgery].

Only a successful cooperation of an oral surgeon and the pathologist can ensure a reliable diagnosis. The authors have analyzed operations performed during 1990 at outpatient clinic of the Department of Oral and Maxillofacial Surgery, University of Zagreb, School of Dentistry. Clinical appearance of the disease and clinical diagnosis sometimes enable us to recognize the real nature of the disease.

[The effect of lead exposure on pathohistological changes in the liver and kidney in relation to age in rats].

Histopathological alterations in the liver and kidneys were examined in adult female rats and in their offspring form two matings after oral exposure to 7500 ppm lead (acetate) in drinking water. The length of exposure was up to 20 weeks. To estimate the reversibility of the effects in a number of exposed females lead administration was discontinued five weeks before their second breeding with unexposed males (the recovered group).

Serotonin and norepinephrine in the spinal cord of man.

The content of serotonin (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and norepinephrine (NE) was analysed in 71 human spinal cords obtained post-mortem. The highest content of 5-HT, 5-HIAA and NE was found in the lumbar enlargement of the spinal cord. 5-HT and 5-HIAA content increased from fetal to adult spinal cord whereas the content of NE decreased.

Interaction of cadmium, zinc and copper in relation to smoking habit, age and histopathological findings in human kidney cortex.

In this study the concentrations of cadmium, zinc and copper were determined by atomic absorption spectrophotometry in 51 post mortem kidney cortex samples. A histopathological examination of the kidney was also performed. These parameters, together with age and smoking habit, were statistically related by means of factor analysis.

Chronic and reproduction studies in rats exposed to gasifier ash leachates.

Ash from the coal gasification process contains a broad spectrum of elements which through leaching (gasifier ash leachates) may enter into the environment. The health effect of such leachates i.e.

Simultaneous reduction of radioactive strontium, caesium and iodine retention by single treatment in rats.

The effect of a mixture of calcium alginate, iron (III) ferrocyanide and potassium iodide added to rat diet on 85Sr, 137Cs and 131I metabolism and health was investigated in female rats after four weeks of treatment. The retention of these radioisotopes was determined in the whole body and critical organs six days after 85 Sr and 137CS and one day after 131I oral administration. The health effect of the mixture was evaluated by measuring body weights, haematological parameters, concentrations of iron, zinc and manganese in the kidneys, liver and femur, bone parameters (femur composition and morphometry) and by a histopathological examination.

Chronic studies in rats exposed to liquid effluent from coal gasification process.

The health effects of the E-effluent (water for quenching ash) from a coal gasification plant were assayed in a chronic experiment (16 month exposure) and a three generation reproduction study. Animals exposed to 100% E-effluent had an increased daily intake of various inorganic elements (Fe, Cu, K, I, Se, Cd, Hg, Pb, As, F and Cr). In spite of that, the exposed and control animals had the same mortality rate, haematological findings, urinary protein excretion, trace element concentrations in kidneys, liver and femur, bone composition and morphometry, and histological findings.

Toxicologic studies of emissions from coal gasification process. I. Subchronic feeding studies.

The increasing use of new sources of energy may result in additional contamination of the human environment with inorganic and organic pollutants which are not yet adequately investigated with regard to their potential impact on human health. However, some evidence exists that several trace inorganic and organic contaminants found in coal processing residues may constitute potential health problems. Therefore, the comparative biological hazards of solid wastes and effluents from a Lurgi coal gasification plant were initially evaluated using acute and chronic feeding experiments in male and female rats.

[Pathologic changes of the placenta in normal labor].

A total of 73 placentas of at-term newborns with a normal course of pregnancy and delivery were morphologically examined. In 6 of them unexpected extensive changes were evidenced: placentitis in 5 cases (3 suppurative) and the hyaline thrombosis of numerous blood vessels in one case. On the basis of these observations the authors recommend systematic pathohistological examinations of the placenta also in so-called normal deliveries.