Publications by authors named "Bumkyu Choi"
Article Synopsis
- Heterotypic polyubiquitin chains formed through ubiquitin multimerization are crucial for regulating protein functions and degradation in cells.
- A new method allows for the chemical diversification of these chains, making it easier to create various functionalized derivatives for study.
- This research highlights the importance of branch positions in the ubiquitin chains, influencing the regulation of ubiquitin-mediated reactions and expanding our understanding of ubiquitin codes.
Growing interest has been focused on the roles of microglia as sentinels and effector cells that guard diverse pathological milieu in the brain. Here, it has been reported that microglial TLR2 is a crucial molecule that confers innate and adaptive immunity against brain tumor. TLR2 is preferentially expressed on microglia, brain-resident immune cells, in the tumor-bearing cerebral hemisphere of mouse and rat intracranial tumor models.
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