REIMAGINE: A central nervous system basket trial showing safety and efficacy of vafidemstat on aggression in different psychiatric disorders.

Aim: Vafidemstat is a brain-penetrant, orally bioavailable, small molecule irreversible inhibitor of the histone lysine-specific demethylase KDM1A (also known as LSD1), which corrects memory deficits and behavior alterations including aggression and social interaction deficits in preclinical models.

Methods: Here, we report the results of REIMAGINE, a phase IIa, single-center, open-label, one-arm basket trial that evaluated the safety and efficacy of vafidemstat on aggression in adult patients with borderline personality disorder (BPD), attention-deficit/hyperactivity disorder (ADHD), and autistic spectrum disorder (ASD). Participants received 1.

Far cortical locking versus standard locking screw fixation in simulated femoral fractures: A biomechanical meta-analysis.

Introduction: Far cortical locking (FCL) is a concept of locking plate fixation with reduced stiffness and symmetric micromotion to improve callus formation. The goal of our study was to review biomechanical data evaluating FCL plate and screw fixation versus standard locking (SL) plate and screw fixation by analyzing studies of cadaveric and synthetic bone models to draw biomechanical conclusions.

Methods: Biomechanical studies that compared FCL and SL plate fixation for simulated femoral fractures were reviewed for construct stiffness, load to failure, axial motion at the near and far cortices, and the difference between near and far cortical axial motion to demonstrate motion symmetry.

Oxidation of Ammonia Catalyzed by a Molecular Iron Complex: Translating Chemical Catalysis to Mediated Electrocatalysis.

Ammonia is a promising candidate in the quest for sustainable, clean energy. With its capacity to serve as an energy carrier, the oxidation of ammonia opens avenues for carbon-neutral approaches to address worldwide growing energy needs. We report the catalytic chemical oxidation of ammonia by an Earth-abundant transition metal complex, trans-[LFe(MeCN)][PF], where L is a macrocyclic ligand bearing four N-heterocyclic carbene (NHC) donors.

Synthesis and Reactivity of Fe(II) Complexes Containing Cis Ammonia Ligands.

The development of earth-abundant transition-metal complexes for electrocatalytic ammonia oxidation is needed to facilitate a renewable energy economy. Important to this goal is a fundamental understanding of how ammonia binds to complexes as a function of ligand geometry and electronic effects. We report the synthesis and characterization of a series of Fe(II)-NH complexes supported by tetradentate, facially binding ligands with a combination of pyridine and -heterocyclic carbene donors.

Payments for ecosystem services programs: A global review of contributions towards sustainability.

Payments for ecosystem services programs (PESPs) are increasingly being adopted globally to enhance sustainability outcomes. There are also hundreds of studies yearly on various aspects of PESPs, but research on their contributions to sustainability of communities and the ecosystems they depend upon at the global scale are rare. Our global review explores twelve key characteristics of PESPs at three different phases (inputs - implementation - outputs and outcomes) and their relationship types of these characteristics to sustainability outcomes.

Just keep swimming? Observations of resting behavior in gray reef sharks Carcharhinus amblyrhynchos (Bleeker, 1856).

Understanding the respiratory modes of sharks has important implications for studying the metabolism, energetics, and behavioral strategies of different species. Here we provide the first reported observations of resting behavior in the gray reef shark Carcharhinus amblyrhynchos, a species typically considered an obligate ram ventilator. Observations were made at several locations in the Republic of Seychelles, where sharks were found resting under reef ledges and were unresponsive to the presence of divers.

Orthopaedic Out of Bed Project (OOBP): improving early mobilisation following femoral fracture using a therapy-led education programme.

Delayed mobilisation following hip fracture surgery is detrimental to patients and health systems. Prolonged hospital stay additionally results in decreased function and increased mortality. Our hospital was underperforming against the national metric for mobilisation by the day after surgery and physiotherapists were the primary healthcare professionals expected to do this.

Single-Crystal to Single-Crystal Transformations: Stepwise CO Insertions into Bridging Hydrides of [(NHC)CuH] Complexes.

Mechanistic studies of substrate insertion into dimeric [(NHC)CuH] (NHC=N-heterocyclic carbene) complexes with two bridging hydrides have been shown to require dimer dissociation to generate transient, highly reactive (NHC)Cu-H monomers in solution. Using single-crystal to single-crystal (SC-SC) transformations, we discovered a new pathway of stepwise insertion of CO into [(NHC)CuH] without complete dissociation of the dimer. The first CO insertion into dimeric [(IPr*OMe)CuH] (IPr*OMe=N,N'-bis(2,6-bis(diphenylmethyl)-4-methoxy-phenyl)imidazole-2-ylidene) produced a dicopper formate hydride [(IPr*OMe)Cu] (μ-1,3-O CH)(μ-H).

Injury-Transplantation Interval-Dependent Amelioration of Axonal Degeneration and Motor Deficit in Rats with Penetrating Traumatic Brain Injury.

Penetrating traumatic brain injury (pTBI) is increasingly survivable, but permanently disabling as adult mammalian nervous system does not regenerate. Recently, our group demonstrated transplant location-dependent neuroprotection and safety of clinical trial-grade human neural stem cell (hNSC) transplantation in a rodent model of acute pTBI. To evaluate whether longer injury-transplantation intervals marked by chronic inflammation impede engraftment, 60 male Sprague-Dawley rats were randomized to three sets.

A reflex testing protocol using two multivariate index assays improves the risk assessment for ovarian cancer in patients with an adnexal mass.

Objectives: Patients with adnexal masses suspicious for malignancy benefit from referral to oncology specialists during presurgical assessment of the mass. OVA1 is a multivariate assay using a five-biomarker panel which offers high overall and early-stage sensitivity. However, OVA1 has a high false-positive rate for benign masses.

Validation of a deep neural network-based algorithm supporting clinical management of adnexal mass.

Background: Conservative management of adnexal mass is warranted when there is imaging-based and clinical evidence of benign characteristics. Malignancy risk is, however, a concern due to the mortality rate of ovarian cancer. Malignancy occurs in 10-15% of adnexal masses that go to surgery, whereas the rate of malignancy is much lower in masses clinically characterized as benign or indeterminate.

Mechanistic Studies of Carbonyl Allylation Mediated by (NHC)CuH: Isoprene Insertion, Allylation, and β-Hydride Elimination.

The ability of Cu-H complexes to undergo selective insertion of unsaturated hydrocarbons under mild conditions has rendered them valuable, versatile catalysts. The direct formation of Cu allyl intermediates from unfunctionalized 1,3-dienes and transient Cu hydrides is an appealing strategy for upgrading conjugated diene feedstocks. However, empirical mechanistic studies of the underlying elementary steps and characterization of key intermediates in Cu-H catalysis are sparse.

Hydrogen Atom Abstraction from an Os(NH) Complex Generates an Os(NH) Complex: Experimental and Computational Analysis of the N-H Bond Dissociation Free Energies and Reactivity.

Double hydrogen atom abstraction from (TMP)Os(NH) (TMP = tetramesitylporphyrin) with phenoxyl or nitroxyl radicals leads to (TMP)Os(NH). This unusual bis(amide) complex is diamagnetic and displays an N-H resonance at 12.0 ppm in its H NMR spectrum.

Isolation of a Cu-H Monomer Enabled by Remote Steric Substitution of a -Heterocyclic Carbene Ligand: Stoichiometric Insertion and Catalytic Hydroboration of Internal Alkenes.

Transient Cu-H monomers have long been invoked in the mechanisms of substrate insertion in Cu-H catalysis. Their role from Cu-H aggregates has been mostly inferred since ligands to stabilize these monomeric intermediates for systematic studies remain limited. Within the last decade, new sterically demanding -heterocyclic carbene (NHC) ligands have led to isolable Cu-H dimers and, in some cases, spectroscopic characterization of Cu-H monomers in solution.

Weakening the N-H Bonds of NH Ligands: Triple Hydrogen-Atom Abstraction to Form a Chromium(V) Nitride.

Weakening and cleaving N-H bonds is crucial for improving molecular ammonia (NH) oxidation catalysts. We report the synthesis and H-atom-abstraction reaction of bis(ammonia)chromium porphyrin complexes Cr(TPP)(NH) and Cr(TMP)(NH) (TPP = 5,10,15,20-tetraphenyl--porphyrin and TMP = 5,10,15,20-tetramesityl--porphyrin) using bulky aryloxyl radicals. The triple H-atom-abstraction reaction results in the formation of Cr(por)(≡N), with the nitride derived from NH, as indicated by UV-vis and IR and single-crystal structural determination of Cr(TPP)(≡N).

Assessing fetal human neural stem cells tumorigenicity potential in athymic rats with penetrating traumatic brain injury (pTBI).

Traumatic brain injuries (TBI) often produce disability in survivors due to unresolved inflammation and progressive neurodegeneration. The central nervous system in mammals is incapable of self-repair. Two decades of preclinical studies and clinical trials have provided insights into TBI pathophysiology that could be utilized to develop clinically relevant therapy.

Exhaled gases and the potential for cross-infection noninvasive ventilation machines.

https://bit.ly/3EdvtY6.

Molecular Catalysts with Diphosphine Ligands Containing Pendant Amines.

Pendant amines play an invaluable role in chemical reactivity, especially for molecular catalysts based on earth-abundant metals. As inspired by [FeFe]-hydrogenases, which contain a pendant amine positioned for cooperative bifunctionality, synthetic catalysts have been developed to emulate this multifunctionality through incorporation of a pendant amine in the second coordination sphere. Cyclic diphosphine ligands containing two amines serve as the basis for a class of catalysts that have been extensively studied and used to demonstrate the impact of a pendant base.

Controlling Reaction Routes in Noble-Metal-Catalyzed Conversion of Aryl Ethers.

Hydrogenolysis and hydrolysis of aryl ethers in the liquid phase are important reactions for accessing functionalized cyclic compounds from renewable feedstocks. On supported noble metals, hydrogenolysis is initiated by a hydrogen addition to the aromatic ring followed by C-O bond cleavage. In water, hydrolysis and hydrogenolysis proceed by partial hydrogenation of the aromatic ring prior to water or hydrogen insertion.

Integrating Social Learning, Adaptive Capacity and Climate Adaptation for Regional Scale Analysis: A Conceptual Framework.

The impact of climate-related changes on northern Canada's renewable resource sectors makes bolstering adaptive capacity an urgent imperative throughout the region. Although social learning is a key ingredient of adaptive capacity, our understanding of the relationships among social learning, adaptive capacity, and climate change adaptation is limited. Building on previous conceptual and empirical studies, this paper develops a framework that clarifies the interactions among social learning, adaptive capacity and climate change adaptation pertinent to a regional scale of analysis.

Influence of Surface and Structural Variations in Donor-Acceptor-Donor Sensitizers on Photoelectrocatalytic Water Splitting.

Conjugated organic chromophores composed of linked donor (D) and acceptor (A) moieties have attracted considerable attention for photoelectrochemical applications. In this work, we compare the optoelectronic properties and photoelectrochemical performance of two D-A-D structural isomers with thiophene--carboxylic acid ( denotes 3 and 2 positions) derivatives and 2,1,3-benzothiadiazole as the D and A moieties, respectively. 5,5'-(Benzo[][1,2,5]thiadiazole-4,7-diyl)bis(thiophene-3-carboxylic acid), , and 5,5'-(benzo[][1,2,5]thiadiazole-4,7-diyl)bis(thiophene-2-carboxylic acid), , were employed in the study to understand how structural isomers affect surface attachments within chromophore-catalyst assemblies and their influence on charge-transfer dynamics.