Ophthalmic Manifestations in Patients with Blood Malignancies.

Ocular complications can occur in up to 90% of patients with blood malignancies. Such complications range from direct infiltration to local hemostatic imbalance and treatment-related toxicity. This narrative review is based on a systematic computerized search of the literature conducted until January 2024 and examines the common ocular complications associated with blood cancers.

Primary vs. pre-emptive anti-seizure medication prophylaxis in anti-CD19 CAR T-cell therapy.

Introduction: Seizures may occur in up to 30% of non-Hodgkin lymphoma patients who received anti-CD19 CAR T-cell therapy, yet the optimal anti-seizure medication (ASM) prevention strategy has not been thoroughly investigated.

Methods: Consecutive patients affected by refractory non-Hodgkin lymphoma who received anti-CD19 CAR T-cells were included. Patients were selected and assessed using similar internal protocols.

Extraction of traditional COP-based features from COM sway in postural stability evaluation.

Postural control during quiet standing is evaluated by analyzing CoP sway, easily measured using a force platform. However, recent proliferation of motion tracking systems made easily available an estimate of the CoM location. Traditional CoP-based measures presented in literature provide information about age-related changes in postural stability and fall risk.

Affordable, automatic quantitative fall risk assessment based on clinical balance scales and Kinect data.

The problem of a correct fall risk assessment is becoming more and more critical with the ageing of the population. In spite of the available approaches allowing a quantitative analysis of the human movement control system's performance, the clinical assessment and diagnostic approach to fall risk assessment still relies mostly on non-quantitative exams, such as clinical scales. This work documents our current effort to develop a novel method to assess balance control abilities through a system implementing an automatic evaluation of exercises drawn from balance assessment scales.

Simulation of cupulolithiasis and canalolithiasis by an animal model.

The physical mechanisms responsible for cupulolithiasis and canalolithiasis have been investigated by two groups of experiments in isolated posterior semicircular canal (SCC) of frog (Rana esculenta L.). First, clouds of 10-30 isolated otoconia were let to fall (snowfall of otoconia) either through the ampulla onto the cupula, or inside the long arm of the canal, opposite to the cupula.

Towards objective evaluation of balance in the elderly: validity and reliability of a measurement instrument applied to the Tinetti test.

The aim of the present study was the validation of an instrument for evaluating balance, applied to the Tinetti test. Trunk inclination was measured by inclinometers during the Tinetti test in 163 healthy participants scoring 28/28 in the Tinetti scale (controls: 92 women, 71 men; age 19-85 years), and 111 residents in old people's homes, able to autonomously perform the test, but scoring less than 28/28 (test group: 78 women, 33 men; age 55-96 years). Trunk inclination was quantified by 20 parameters, whose standardized values were summed and provided an overall performance index (PTOT).

About the effects of velocity saturation on smooth pursuit.

By means of simple simulations and based on experimental results from the literature, it is argued that correct consideration of the well known velocity saturation of the smooth pursuit eye movement system may suggest new insight into some intriguing aspects of this system's behavior.

Convection, buoyancy or endolymph expansion: what is the actual mechanism responsible for the caloric response of semicircular canals?

The mechanisms underlying caloric nystagmus are still matter of debate. The original theory proposed by Barany and more recently by Pau and Limberg suggested that convective endolymphatic currents were involved. In contrast Gentine et al.

Towards objective quantification of the Tinetti test.

The Tinetti test is a widespread test for assessing motor control in the elderly, which could also be usefully applied in neurology. At present it uses a qualitative measurement scale. As a first step towards its objective quantification, trunk inclination was measured during the test by two inclinometers and quantified by descriptive parameters.

Measurement on Tinetti test: instrumentation and procedures.

A measurement system and associate signal processing procedures for quantifying subject's performance during the performance-oriented assessment of balance as defined in Tinetti test (TT) is described. It is based on two inclinometers measuring trunk inclination in two orthogonal planes. Signals from the transducers are acquired by a PC through A/DC board.

Effects of caloric stimuli on frog ampullar receptors.

The observation that caloric nystagmus can be evoked even in microgravity conditions argues against Barany's convective theory. To justify this result, gravity-independent mechanisms (mainly endolymphatic volume changes and direct action of the temperature on vestibular sensors) are believed to contribute to caloric-induced activation of vestibular receptors. To define the importance of both gravity-dependent and gravity-independent mechanisms, the posterior semicircular canal of the frog was thermally stimulated by a microthermistor positioned close to the sensory organ.

Ocular fixation index and mathematical models.

Ocular fixation test and ocular fixation index (OFI) never have been interpreted in terms of mathematical models, despite their widespread diffusion. However, ocular fixation is a typical case of visual-vestibular interaction, and mathematical models have proven very helpful in interpreting some mechanisms of this interaction, e.g.

Manuo-ocular coordination in target tracking. I. A model simulating human performance.

During eye tracking of a self-moved target, human subjects' performance differs from eye-alone tracking of an external target. Typical latency between target and eye motion onsets is shorter, ocular smooth pursuit (SP) saturation velocity increases and the maximum target motion frequency at which the SP system functions correctly is higher. Based on a previous qualitative model, a quantitative model of the coordination control between the arm motor system and the SP system is presented and evaluated here.

The performance of different pressure pulse generators for extracorporeal lithotripsy: a comparison based on commercial lithotripters for kidney stones.

By using needle hydrophones and a PC-controlled experimental set-up, the acoustic output of 10 commercial extracorporeal shock-wave lithotripters has been measured. The pressure field was measured in the focus, along the beam axis, in the focal plane and "at the skin level" (a plane orthogonal to the beam axis, 5 cm backward from the focus, assumed as the entrance site of the pressure pulse into the patient's body). The set of tested instruments included the three technologies nowadays in use to generate the pressure pulse, namely electrohydraulic, electromagnetic and piezoelectric.

Effects of hydrostatic pressure on sensory discharge in frog semicircular canals.

The effects of endolymphatic and perilymphatic pressure changes on resting and mechanically evoked responses were studied in isolated posterior semicircular canals of the frog. The results demonstrated that ampullar receptors are extremely sensitive to hydrostatic pressure changes (0.25 mm H2O were sufficient to produce distinct changes), being inhibited by endolymphatic pressure increases and facilitated by perilymphatic ones.

Expert systems as a diagnostic aid in otoneurology.

Expert systems (ES) are a new tool for information processing developed by the branch of computer science known as artificial intelligence. ES are capable of solving problems in a given domain by using the knowledge and emulating the behaviour of specialists in that field. ES can be used as powerful tools for education since they are able to justify their own conclusions and to make the underlying reasoning explicit.

Cross-coupled effects of repeated vestibular and optokinetic stimulations on the dynamics of the vestibulo-ocular and optokinetic reflexes in the cat.

Cats were submitted to repeated step stimulations either vestibular or optokinetic. Regardless of which of the two stimuli was used, dynamic modifications were observed in both vestibulo-ocular response and optokinetic after-nystagmus (OKAN). The progressive changes in post-rotational nystagmus and OKAN were quantified by measuring the duration of their primary phase.

[Current computerized support for vestibular function tests.I. Expert systems and their clinical applications].

Expert Systems are a new method developed by the branch of Computer Science known as Artificial Intelligence in order to make available the knowledge and the expertise of the specialists in a certain domain of the science to other operators in the same field. Most of their applications belong to the medical domain. In this paper the main features of the expert systems are briefly described.

[Current computerized support for vestibular function tests. II. An expert system for the classification of vertigo].

A computerized system (VERTIGO) aimed to the classification and diagnosis of different types of vertigo has been developed. It is based on the shell EXPERT (Weiss and Kulikowski, 1979). At present only the findings arising from patient history are considered as input data and the diagnostic possibilities of the system have been limited to the differential diagnosis of vertigo due to peripheral vestibular disorders.

Velocity characteristics of smooth pursuit eye movements to different patterns of target motion.

Horizontal smooth pursuit eye movements were recorded in normal subjects in response to different patterns of target motion that was either periodic or not. Periodic patterns were triangular and sinusoidal waves. Non-periodic patterns were ramps with either constant or sinusoidally varying velocity.

Harmonic versus impulsive acceleration testing of the vestibulo-ocular reflex in normal humans.

Vestibulo-ocular reflex (VOR) was tested in 9 normal humans by using both harmonic (sinusoidal) and impulsive (post-rotatory) angular accelerations. VOR gain and main time constant were 0.49 +/- 0.

New experimental data on cat's optokinetic responses. Is there need to revise previous models of the optokinetic reflex?

New data on cat's optokinetic reflex (OKR) provided by Godaux and Vanderkelen (1984) have been interpreted by using a nonlinear model of OKR previously proposed by the authors. A general agreement between experimental data and theoretical predictions was obtained. In particular, the steep decrease of OKR gain observed experimentally at high frequencies appeared as a straightforward consequence of the intrinsic nonlinearity of OKR.